Results 31 to 40 of about 22,513 (247)

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Acquired Haemophilia Occurring in Association With Bullous Pemphigoid

JEADV Clinical Practice
Acquired haemophilia A (AHA) is a rare condition due to neutralizing antibodies against Factor VIII and can result in severe bleeding manifestations. The association of AHA with bullous pemphigoid (BP) is rare, most frequently observed in the elderly ...
Wen Yang Benjamin Ho, Zi Teng Chai, Haur Yueh Lee, Yen Loo Lim   +3 more
doaj   +1 more source

Haemophilia care in Iraq; a multi-centre study

Journal of the Pakistan Medical Association
Objectives: To evaluate the level of care available to haemophilia patients. Method: The descriptive, retrospective analytical study was conducted from December 15, 2020, to March 1, 2021, after approval from the Mustansiriyah University, Baghdad ...
Nidal Karim Al Rahal, Meaad Kadhum Hassan, Obeida Amir Abid, Azeezah Mohammed Mohsin   +3 more
doaj   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Plasma levels of IL-1β and IL-37 in patients with severe haemophilia

Journal of International Medical Research, 2020
Objective Haemophilia A and B are disorders caused by the lack of clotting factors VIII and IX, respectively. Repeated bleeding into the same joint leads to haemophilic arthropathy (HA).
Pei-Chin Lin, Shyh-Shin Chiou, Wan-Yi Hsu, Yu-Mei Liao, Shih-Pien Tsai, Hsiu-Lan Su, Ping-Tao Lu, Yu-Hsin Tseng   +7 more
doaj   +1 more source

Assessing policy and operational barriers to tranexamic acid utilization in treating postpartum hemorrhage in Kano, Lagos, and Niger states

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study explores the barriers to the use of tranexamic acid (TXA) for the management of postpartum hemorrhage (PPH) and provides recommendations to improve its use. Methods We conducted a mixed‐methods assessment involving 229 healthcare professionals in Kano, Lagos, and Niger States of Nigeria.
Chukwunonso Nwaokorie, Aisha Abdullahi, Naanma Kangkum, Valentine Amasiatu, Eric Aigbogun, Uchenna Igbokwe   +5 more
wiley   +1 more source

Physical activity patterns in people with haemophilia with and without arthropathy: a cross-sectional study using wearable sensors

Thrombosis Journal
Background In haemophilia, recurrent joint bleeding often results in joint destruction, which in turn leads to reduced physical activity (PA) and decreased quality of life (QOL).
Yuya Mawarikado, Midori Shima, Naoki Matsumoto, Asuka Sakata, Ryohei Kawasaki, Kohei Tatsumi, Tetsuhiro Soeda, Suguru Harada, Naoto Seriu, Yusuke Inagaki, Akira Kido, Keiji Nogami   +11 more
doaj   +1 more source

Prothrombotic risk mutations and polymorphisms in patients with hemophilia A – a preliminary study / Polimorfismele și mutațiile cu risc protrombotic la pacienții cu hemofilie A - studiu preliminar

Romanian Journal of Laboratory Medicine, 2015
Introducere. Necesitatea explicării heterogenităţii clinice la pacienţii cu hemofilie (PcH), cu acelaşi grad de severitate sau cu aceeaşi mutaţie, a determinat preocupările de evaluare a coexistenţei polimorfismelor şi mutațiilor cu risc protrombotic ...
Boeriu Estera, Şerban Margit, Neuner Bruno, Arghirescu Smaranda Teodora, Ioniţă Hortensia, Ursu Cristina Emilia, Ritli Ladislau, Talpoş Şerban, Jinca Cristian, Pătraşcu Jenel Marian   +9 more
doaj   +1 more source

The impact of severe haemophilia and the presence of target joints on health-related quality-of-life

Health and Quality of Life Outcomes, 2018
Background Joint damage remains a major complication associated with haemophilia and is widely accepted as one of the most debilitating symptoms for persons with severe haemophilia.
Jamie O’Hara, Shaun Walsh, Charlotte Camp, Giuseppe Mazza, Liz Carroll, Christina Hoxer, Lars Wilkinson   +6 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source