AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source
Current Perspectives on Radiosensitizers in Cancer Radiotherapy. [PDF]
Ruan H, Li Y, Chen S.
europepmc +1 more source
A Monolithic Janus Hydrogel Pressure Sensor for Wearable Motion and Physiological Monitoring
This work reports a monolithic Janus hydrogel pressure sensor featuring integrated conductive PEDOT and insulating PEGDA layers. The fabricated device achieves a rapid response time, a wide operating range, and good cyclic durability. The sensor demonstrates robust performance in tracking dynamic human joint motions, offering a scalable strategy for ...
Syed Atif Ali +7 more
wiley +1 more source
Hafnium-Substituted Wells-Dawson Polyoxometalate as a High-Performance Contrast Agent for Transmission Electron Microscopy of Biological Ultrastructure. [PDF]
Milosavljević A +7 more
europepmc +1 more source
Combining recently established two ground‐breaking concepts, the adoption of WCAs and the use of alkoxyalkylamine‐based solvents in electrolyte formulations for rechargeable magnesium metal batteries, has led to unexpectedly unsuccessful electrochemical Mg plating/stripping performance. Comprehensive experimental and computational analyses revealed the
Toshihiko Mandai +4 more
wiley +1 more source
Nanomedicine in 2026: Illustrative Quantitative Analyses of EPR Heterogeneity, Clinical Trial Attrition, and Emerging Horizons for Active Nanotherapeutics. [PDF]
Fayez SM.
europepmc +1 more source
Nanoparticle‐Mediated Bubble Suppression During Droplet Solidification for Mechanical Reinforcement
Nanoparticles mediate droplet solidification by raising nucleation temperature, refining dendrites, and slowing freezing‐front advance, thereby suppressing trapped air bubbles in droplet‐based 3D printing. This strategy reduces bubble volume fraction by ∼35% and increases compressive strength by up to 39%, offering a low‐cost route to stronger printed ...
Runmiao Gao +10 more
wiley +1 more source
Solution-Processed High-k HfO<sub>2</sub> Gate Insulator for High-Performance Indium-Zinc-Oxide Thin-Film Transistors: Optimisation of Annealing Temperature and Insulator Thickness. [PDF]
Sairike J +4 more
europepmc +1 more source
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu +9 more
wiley +1 more source
High-speed energy-efficient memristor confined in sub-5 nm space with elemental oxygen reservoir layer. [PDF]
Li C +10 more
europepmc +1 more source

