Results 141 to 150 of about 11,068,075 (352)

NF-κB is Required for Survival of Immature Auditory Hair Cells In Vitro [PDF]

, 2018
Damage to auditory hair cells in the inner ear as a consequence of aging, disease, acoustic trauma, or exposure to ototoxins underlies most cases of hearing impairment.
Albinger-Hegyi, Andrea, Bodmer, Daniel, Monge, Arianne, Nagy, Ivana, Schmid, Stephan   +4 more
core  

Review of Hair Cell Synapse Defects in Sensorineural Hearing Impairment

Otology and Neurotology, 2013
Objective To review new insights into the pathophysiology of sensorineural hearing impairment. Specifically, we address defects of the ribbon synapses between inner hair cells and spiral ganglion neurons that cause auditory synaptopathy. Data Sources and
T. Moser, Friederike Predoehl, A. Starr
semanticscholar   +1 more source

Stable, Easy‐to‐Handle, Fully Autologous Electrospun Polymer‐Peptide Skin Equivalent for Severe Burn Injuries

Advanced Functional Materials, EarlyView.
A bioengineered skin equivalent composed of electrospun poly(ε‐caprolactone) (PCL) and the bioactive peptide Fmoc‐FRGD is developed for severe burn treatment. This scaffold promotes full‐thickness skin regeneration by supporting cellular adhesion and integration. In‐vitro and in‐vivo studies show enhanced mechanical stability, accelerated wound closure,
Dana Cohen‐Gerassi, Marina BenShoshan, Adi Liiani, Tomer Reuveni, Offir Loboda, Moti Harats, Josef Haik, Itzhak Binderman, Yosi Shacham‐Diamand, Amit Sitt, Ayelet Di Segni, Lihi Adler‐Abramovich   +11 more
wiley   +1 more source

Disruption of Intracellular Calcium Regulation Is Integral to Aminoglycoside-Induced Hair Cell Death

Journal of Neuroscience, 2013
Intracellular Ca2+ is a key regulator of life or death decisions in cultured neurons and sensory cells. The role of Ca2+ in these processes is less clear in vivo, as the location of these cells often impedes visualization of intracellular Ca2+ dynamics ...
Robert Esterberg, D. Hailey, A. Coffin, D. Raible, E. Rubel   +4 more
semanticscholar   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

The FEDBD plasma’s quantitative investigation of skin parameters: Skin elasticity, thickness, density, tissue oxygenation, perfusion, and edema

Heliyon
This study used the FEDBD plasma device for skin rejuvenation in animal samples. There were two groups of six male Wistar rats. Before starting the treatment, immediately after the treatment, the fourth week, and the tenth week of follow-up, biometric ...
Parisa Charipoor, Mohammad Ali Nilforoushzadeh, Mohammadreza Khani, Maryam Nouri, Erfan Ghasemi, Mohammad Amir Amirkhani, Mohammad Eftekhari, Babak Shokri   +7 more
doaj  

Proliferative regeneration of zebrafish lateral line hair cells after different ototoxic insults.

PLoS ONE, 2012
Sensory hair cells in the zebrafish lateral line regenerate rapidly and completely after damage. Previous studies have used a variety of ototoxins to kill lateral line hair cells to study different phenomena including mechanisms of hair cell death and ...
Scott M Mackenzie, David W Raible
doaj   +1 more source

Functional Mechanotransduction Is Required for Cisplatin-Induced Hair Cell Death in the Zebrafish Lateral Line

Journal of Neuroscience, 2013
Cisplatin, one of the most commonly used anticancer drugs, is known to cause inner ear hair cell damage and hearing loss. Despite much investigation into mechanisms of cisplatin-induced hair cell death, little is known about the mechanism whereby ...
Andrew J Thomas, D. Hailey, Tamara M. Stawicki, Patricia Wu, A. Coffin, E. Rubel, D. Raible, J. Simon, Henry C. Ou   +8 more
semanticscholar   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

CHANGE IN ENZYME ACTIVITY AND RIBONUCLEIC ACID CONCENTRATION WITHIN THE EPIDERMAL CELL OF THE RAT DURING THE GROWTH STAGE OF THE HAIR CYCLE [PDF]

, 1956
Robert D. Griesemer
openalex   +1 more source