Results 151 to 160 of about 212,566 (266)

Myosin 7a is required for maintaining the transducing stereocilia and for force transmission to the MET channel during cochlear hair cell development. [PDF]

J Physiol
Underhill A, Webb S, Grandi FC, Carlton AJ, Jeng JY, Johnson SL, Kros CJ, Marcotti W.   +7 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

VASCilia is an open-source, deep learning-based tool for 3D analysis of cochlear hair cell stereocilia bundles. [PDF]

PLoS Biol
Kassim YM, Rosenberg DB, Das S, Wang X, Huang Z, Rahman S, Al Shammaa IM, Salim S, Huang K, Renero A, Ninoyu Y, Friedman RA, Indzhykulian AA, Manor U.   +13 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Tinnitus in Normal-Hearing Individuals: Is Outer Hair Cell Dysfunction the Mechanism? [PDF]

J Clin Med
Chimona T, Vrentzou M, Erotokritakis E, Tsakiraki E, Asimakopoulou P, Papadakis C.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

E2F1-mediated 53BP2 lactylation stabilizes p53 to induce cochlear hair cell apoptosis in mouse age-related hearing loss. [PDF]

Clin Epigenetics
Luo X, Liu J, Zhang C, Yuan W, Qin G.
europepmc   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

NOX2 Contributes to High-Frequency Outer Hair Cell Vulnerability in the Cochlea. [PDF]

Adv Sci (Weinh)
Qi M, Gao Z, Qiu Y, Wang R, Tian K, Yue B, Zhang X, Zhang P, Wu Z, Zhu Q, Liu Z, Ma Z, Zhou X, Han Y, Chen J, Qiu J, Zha D.   +16 more
europepmc   +1 more source

Fundamentals of Thermal Transport and Energy Conversion in Ultra‐High Temperature Ceramics: From Microscale Mechanisms to Macroscopic Properties

Advanced Science, EarlyView.
This review critically examines thermal transport and radiative properties of ultra‐high temperature ceramics for hypersonic flight, advanced nuclear systems, and next‐generation energy conversion devices. It explores phonon–photon–electron interactions, microstructural engineering, thermoelectric conversion, and machine learning‐accelerated multiscale
Zhipeng Pei, Yue Li, Jiayu Xing, Yue Zhu, Ru Zhang, Huan Wu, Zihao Qin, Gang Pei, Man Li   +8 more
wiley   +1 more source