Results 61 to 70 of about 11,093,699 (378)
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]
, 2006 Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core +1 more source
Relating structure and function of inner hair cell ribbon synapses
Cell and Tissue Research, 2015 In the mammalian cochlea, sound is encoded at synapses between inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs). Each SGN receives input from a single IHC ribbon-type active zone (AZ) and yet SGNs indefatigably spike up to hundreds of Hz
C. Wichmann, Tobias Moser
semanticscholar +1 more source
The challenge of hair cell regeneration [PDF]
Experimental Biology and Medicine, 2010 Sensory hair cells of the inner ear are responsible for translating auditory or vestibular stimuli into electrical energy that can be perceived by the nervous system. Although hair cells are exquisitely mechanically sensitive, they can be easily damaged by excessive stimulation by ototoxic drugs and by the effects of aging.
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2014 In humans, auditory hair cells are not replaced when injured. Thus, cochlear hair cell loss causes progressive and permanent hearing loss. Conversely, nonmammalian vertebrates are capable of regenerating lost sensory hair cells.
Yingzi eHe +6 more
doaj +1 more source
Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells. [PDF]
, 1997 Myosin VIIA is expressed by sensory hair cells and has a primary structure predicting a role in membrane trafficking and turnover, processes that may underlie the susceptibility of hair cells to aminoglycoside antibiotics. [3H]Gentamicin accumulation and
Brown, S D M +5 more
core +2 more sources
Designer aminoglycosides prevent cochlear hair cell loss and hearing loss.
Journal of Clinical Investigation, 2015 Bacterial infections represent a rapidly growing challenge to human health. Aminoglycosides are widely used broad-spectrum antibiotics, but they inflict permanent hearing loss in up to ~50% of patients by causing selective sensory hair cell loss.
Markus E. Huth +10 more
semanticscholar +1 more source
Tuning in to cochlear hair cells [PDF]
The Journal of Physiology, 2006 A major quest in hearing research over the last 35 years or so has been, and continues to be, how mammalian hearing achieves its remarkable frequency selectivity and sensitivity over a large frequency range, down from 20 Hz up to over 100 kHz in some species.
Michael G. Evans, Corné J. Kros
openaire +3 more sources
Stem Cell Research & Therapy, 2018 Background Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ear hair cells and treating hearing ...
Jianling Chen +7 more
doaj +1 more source
Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
Frontiers in Cellular Neuroscience, 2020 Hair cells are sensitive to many insults including environmental toxins such as heavy metals. We show here that cadmium can consistently kill hair cells of the zebrafish lateral line.
Caleigh Schmid +4 more
doaj +1 more source
AXR3 and SHY2 interact to regulate root hair development [PDF]
, 2003 Signal transduction of the plant hormone auxin centres on the regulation of the abundance of members of the Aux/IAA family of transcriptional regulators, of which there are 29 in Arabidopsis.
Grierson, C.S., Knox, K., Leyser, O.
core +2 more sources