Results 61 to 70 of about 11,068,075 (352)
Interpretation of the Yak Skin Single-Cell Transcriptome Landscape
Animals, 2023 The morphogenesis of hair follicle structure is accompanied by the differentiation of skin tissue. Mammalian coats are produced by hair follicles. The formation of hair follicles requires signal transmission between the epidermis and dermis.
Qingbo Zheng +11 more
doaj +1 more source
Amplitude death of coupled hair bundles with stochastic channel noise [PDF]
, 2014 Hair cells conduct auditory transduction in vertebrates. In lower vertebrates such as frogs and turtles, due to the active mechanism in hair cells, hair bundles(stereocilia) can be spontaneously oscillating or quiescent. Recently, the amplitude death phenomenon has been proposed [K.-H. Ahn, J. R. Soc.
arxiv +1 more source
Designer aminoglycosides prevent cochlear hair cell loss and hearing loss.
Journal of Clinical Investigation, 2015 Bacterial infections represent a rapidly growing challenge to human health. Aminoglycosides are widely used broad-spectrum antibiotics, but they inflict permanent hearing loss in up to ~50% of patients by causing selective sensory hair cell loss.
Markus E. Huth +10 more
semanticscholar +1 more source
Membrane Thickness Sensitivity of Avian Prestin: Implications [PDF]
arXiv, 2023 Avian prestin is sensitive to membrane thickness as much as mammalian prestin, which undergoes conformational transitions in membrane area and thereby drives length changes of the cylindrical cell body of outer hair cells. The membrane thickness dependence of mammalian prestin stems from changes in hydrophobic profile in conformational states ...
arxiv
Auditory Sensitivity Provided by Self-tuned Critical Oscillations of Hair Cells [PDF]
Proc. Natl. Acad. Sci. USA, Vol. 97,Issue 7, 3183-3188, March 28,
2000, 2000 We introduce the concept of self-tuned criticality as a general mechanism for signal detection in sensory systems. In the case of hearing, we argue that active amplification of faint sounds is provided by a dynamical system which is maintained at the threshold of an oscillatory instability.
arxiv +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Stem Cell Research & Therapy, 2018 Background Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ear hair cells and treating hearing ...
Jianling Chen +7 more
doaj +1 more source
T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1 [PDF]
, 2018 T Cell Leukemia/Lymphoma 1A is expressed during B-cell differentiation and, when overexpressed, acts as an oncogene in mouse (Tcl1a) and human (TCL1A) B-cell chronic lymphocytic leukemia (B-CLL) and T-cell prolymphocytic leukemia (T-PLL). Furthermore, in
Arcelli, D. +9 more
core +2 more sources
Bmi1 regulates auditory hair cell survival by maintaining redox balance
Cell Death and Disease, 2015 Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function
Yan Chen +7 more
semanticscholar +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source