Results 71 to 80 of about 11,093,699 (378)

Interpretation of the Yak Skin Single-Cell Transcriptome Landscape

Animals, 2023
The morphogenesis of hair follicle structure is accompanied by the differentiation of skin tissue. Mammalian coats are produced by hair follicles. The formation of hair follicles requires signal transmission between the epidermis and dermis.
Qingbo Zheng, Na Ye, Pengjia Bao, Tong Wang, Chaofan Ma, Min Chu, Xiaoyun Wu, Siyuan Kong, Xian Guo, Chunnian Liang, Heping Pan, Ping Yan   +11 more
doaj   +1 more source

T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1 [PDF]

, 2018
T Cell Leukemia/Lymphoma 1A is expressed during B-cell differentiation and, when overexpressed, acts as an oncogene in mouse (Tcl1a) and human (TCL1A) B-cell chronic lymphocytic leukemia (B-CLL) and T-cell prolymphocytic leukemia (T-PLL). Furthermore, in
Arcelli, D., Bassi, C., Bresin, A., Caprini, E., Cristofoletti, C., Fiorenza, M. T., Helmer Citterich, M., Narducci, M. G., Ragone, G., Russo, G.   +9 more
core   +2 more sources

Bmi1 regulates auditory hair cell survival by maintaining redox balance

Cell Death and Disease, 2015
Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function
Yan Chen, Li Li, W. Ni, Yiyin Zhang, Shenfei Sun, Dengshun Miao, Renjie Chai, Hong-Fu Li   +7 more
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Individual differences in auditory brainstem response wave characteristics : relations to different aspects of peripheral hearing loss [PDF]

, 2016
Little is known about how outer hair cell loss interacts with noise-induced and age-related auditory nerve degradation (i.e., cochlear synaptopathy) to affect auditory brainstem response (ABR) wave characteristics.
Ernst, Frauke, Jagadeesh, Anoop, Mauermann, Manfred, Verhulst, Sarah   +3 more
core   +4 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration [PDF]

, 2012
Tissue development and regeneration depend on cell-cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properly regenerated tissue are not well understood.
A Uchugonova, Ann M. Haberman, C Lo Celso, CA Jahoda, David G. Gonzalez, E Fuchs, Elizabeth R. Deschene, FM Watt, G Cotsarelis, Giovanni Zito, H Oshima, H Ra, Ichiko Saotome, JB Wallingford, L Rubin, M Eiraku, M Petersson, M Rendl, MV Plikus, Panteleimon Rompolas, S Müller-Röver, SJ Morrison, SK Waghmare, T Tumbar, V Greco, V Greco, Valentina Greco, Y Xie, YV Zhang   +28 more
core   +1 more source

Modulation of hair cell efferents [PDF]

Hearing Research, 2011
Outer hair cells (OHCs) amplify the sound-evoked motion of the basilar membrane to enhance acoustic sensitivity and frequency selectivity. Medial olivocochlear (MOC) efferents inhibit OHCs to reduce the sound-evoked response of cochlear afferent neurons.
Eric Wersinger, Paul A. Fuchs
openaire   +3 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source