Results 71 to 80 of about 11,068,075 (352)

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. [PDF]

, 2011
Notch-mediated lateral inhibition has been reported to regulate auditory hair cell and supporting cell development from common precursors. While the Notch effector genes Hes1, Hes5 and Hey1 are expressed in the developing cochlea, inactivation of either ...
Imayoshi, Itaru, Ito, Juichi, Kageyama, Ryoichiro, Tateya, Ichiro, Tateya, Tomoko   +4 more
core   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

The supporting-cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the inner ear [PDF]

, 1999
After noise- or drug-induced hair-cell loss, the sensory epithelia of the avian inner ear can regenerate new hair cells. Few molecular markers are available for the supporting-cell precursors of the hair cells that regenerate, and little is known about ...
Cotanche, Douglas A, Goodyear, Richard J, Kruger, Robert P, Legan, P Kevin, Raphael, Yehoash, Richardson, Guy P, Warchol, Mark E   +6 more
core   +2 more sources

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

The Rho GTPase Cdc42 regulates hair cell planar polarity and cellular patterning in the developing cochlea

Biology Open, 2015
Hair cells of the organ of Corti (OC) of the cochlea exhibit distinct planar polarity, both at the tissue and cellular level. Planar polarity at tissue level is manifested as uniform orientation of the hair cell stereociliary bundles. Hair cell intrinsic
Anna Kirjavainen, Maarja Laos, Tommi Anttonen, Ulla Pirvola   +3 more
doaj   +1 more source

Understanding Mammalian Hair Follicle Ecosystems by Single-Cell RNA Sequencing

Animals, 2022
Single-cell sequencing technology can fully reflect the heterogeneity of cell populations at the single cell level, making it possible for us to re-recognize various tissues and organs.
Qingbo Zheng, Xiaolan Zhang, Pengjia Bao, Xuelan Zhou, Min Chu, Xian Guo, Chunnian Liang, Heping Pan, Ping Yan   +8 more
doaj   +1 more source

Control of a hair bundle's mechanosensory function by its mechanical load [PDF]

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E1000-9, 2017
Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant and step stimuli in the vestibular and lateral-line systems. We show that a hair cell's function can be controlled experimentally by adjusting its mechanical load.
arxiv   +1 more source

Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration [PDF]

, 2012
Tissue development and regeneration depend on cell-cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properly regenerated tissue are not well understood.
A Uchugonova, Ann M. Haberman, C Lo Celso, CA Jahoda, David G. Gonzalez, E Fuchs, Elizabeth R. Deschene, FM Watt, G Cotsarelis, Giovanni Zito, H Oshima, H Ra, Ichiko Saotome, JB Wallingford, L Rubin, M Eiraku, M Petersson, M Rendl, MV Plikus, Panteleimon Rompolas, S Müller-Röver, SJ Morrison, SK Waghmare, T Tumbar, V Greco, V Greco, Valentina Greco, Y Xie, YV Zhang   +28 more
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line

Frontiers in Cellular Neuroscience, 2017
Inner ear hair cell death leads to sensorineural hearing loss and can be a direct consequence of aminoglycoside antibiotic treatment. Aminoglycosides such as gentamicin are effective therapy for serious Gram-negative bacterial infections such as some ...
Heather Wiedenhoft, Lauren Hayashi, Allison B. Coffin, Allison B. Coffin   +3 more
doaj   +1 more source