Results 61 to 70 of about 543,428 (303)
Postsynaptic Ca2+, but not cumulative depolarization, is necessary for the induction of associative plasticity in Hermissenda [PDF]
, 1993 The neuronal modifications that underlie associative memory in Hermissenda have their origins in a synaptic interaction between the visual and vestibular systems, and can be mimicked by contiguous in vitro stimulation of these converging pathways. At the
Matzel, R. F, Rogers, Ronald F
core +2 more sources
Survival of auditory hair cells [PDF]
Cell and Tissue Research, 2015 The inability of mammals to regenerate auditory hair cells creates a pressing need to understand the means of enhancing hair cell survival following insult or injury. Hair cells are easily damaged by noise exposure, by ototoxic medications and as a consequence of aging processes, all of which lead to progressive and permanent hearing impairment as hair
Michelle L, Seymour, Fred A, Pereira
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Magnetic actuation of hair cells [PDF]
Applied Physics Letters, 2011 The bullfrog sacculus contains mechanically sensitive hair cells whose stereociliary bundles oscillate spontaneously when decoupled from the overlying membrane. Steady-state offsets on the resting position of a hair bundle can suppress or modulate this native motility.
David, Rowland +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids
Cell ReportsSummary: Human pluripotent stem cell-derived cochlear organoids are promising tools for studying human cochlear development and disease. However, the maturation of hair cells in these organoids is slow, requiring 200 days to express the mature outer hair
Tsubasa Saeki +6 more
doaj +1 more source
A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells [PDF]
, 2004 Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell.
Fuchs, Paul A. +7 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Clinical Case ReportsNon‐cultured melanocyte‐keratinocyte transplantation combined with narrowband ultraviolet B (NB‐UVB) therapy is a promising and well‐tolerated treatment for facial hypo‐pigmentation following scarring.
Sona Zare +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 In humans, auditory hair cells are not replaced when injured. Thus, cochlear hair cell loss causes progressive and permanent hearing loss. Conversely, nonmammalian vertebrates are capable of regenerating lost sensory hair cells.
Yingzi eHe +6 more
doaj +1 more source