Results 81 to 90 of about 11,093,699 (378)

The Rho GTPase Cdc42 regulates hair cell planar polarity and cellular patterning in the developing cochlea

Biology Open, 2015
Hair cells of the organ of Corti (OC) of the cochlea exhibit distinct planar polarity, both at the tissue and cellular level. Planar polarity at tissue level is manifested as uniform orientation of the hair cell stereociliary bundles. Hair cell intrinsic
Anna Kirjavainen, Maarja Laos, Tommi Anttonen, Ulla Pirvola   +3 more
doaj   +1 more source

Understanding Mammalian Hair Follicle Ecosystems by Single-Cell RNA Sequencing

Animals, 2022
Single-cell sequencing technology can fully reflect the heterogeneity of cell populations at the single cell level, making it possible for us to re-recognize various tissues and organs.
Qingbo Zheng, Xiaolan Zhang, Pengjia Bao, Xuelan Zhou, Min Chu, Xian Guo, Chunnian Liang, Heping Pan, Ping Yan   +8 more
doaj   +1 more source

The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles [PDF]

, 2006
Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links.
Birch, David G, Goodyear, Richard J, Holt, Jeffrey R, Legan, P Kevin, Locke, Kirsten G, McGee, JoAnn, McMillan, D Randy, Richardson, Guy P, Stauffer, Eric A, Walsh, Edward J, White, Perrin C   +10 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line

Frontiers in Cellular Neuroscience, 2017
Inner ear hair cell death leads to sensorineural hearing loss and can be a direct consequence of aminoglycoside antibiotic treatment. Aminoglycosides such as gentamicin are effective therapy for serious Gram-negative bacterial infections such as some ...
Heather Wiedenhoft, Lauren Hayashi, Allison B. Coffin, Allison B. Coffin   +3 more
doaj   +1 more source

Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs [PDF]

, 2009
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development.
Elgoyhen, Ana Belen, Murthy, Vidya, Taranda, Julian, Vetter, Douglas E.   +3 more
core   +1 more source

Distinguishing hair cell from neural potentials recorded at the round window.

Journal of Neurophysiology, 2014
Almost all patients who receive cochlear implants have some acoustic hearing prior to surgery. Electrocochleography (ECoG), or electrophysiological measures of cochlear response to sound, can identify remaining auditory nerve activity that is the basis ...
M. Forgues, Heather A. Koehn, A. Dunnon, S. Pulver, C. Buchman, O. Adunka, D. Fitzpatrick   +6 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium

iScience, 2023
Summary: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair
Mami Matsunaga, Ryosuke Yamamoto, Tomoko Kita, Hiroe Ohnishi, Norio Yamamoto, Takayuki Okano, Koichi Omori, Takayuki Nakagawa   +7 more
doaj  

A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability. [PDF]

PLoS ONE, 2012
Atonal homolog1 (Atoh1) is a bHLH transcription factor essential for inner ear hair cell differentiation. Targeted expression of Atoh1 at various stages in development can result in hair cell differentiation in the ear. However, the level and duration of
Ning Pan, Israt Jahan, Jennifer Kersigo, Jeremy S Duncan, Benjamin Kopecky, Bernd Fritzsch   +5 more
doaj   +1 more source