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Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice
Hearing Research, 2020Proper functioning of the auditory nerve is of critical importance for auditory rehabilitation by cochlear implants. Here we used the Cldn14-/- mouse to study in detail the effects of Claudin 14 loss on auditory synapses and the auditory nerve. Mutations in the tight junction protein Claudin 14 cause autosomal recessive non-syndromic hearing loss ...
J Schulze +2 more
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Two Modes of Auditory Hair Cell Loss following Acoustic Overstimulation in the Avian Inner Ear
ORL, 1997To determine the type of cell death occurring and how the removal of damaged cells proceeds following overstimulation, we examined chick basilar papillae using an in situ DNA nick end labeling method and transmission electron microscopy. Two distinct modes of hair cell loss were identified.
Masahiro Takayama +5 more
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Hearing Research, 1992
Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell.
Peter Dallos, Mary Ann Cheatham
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Inner hair cell (IHC) recordings were made from second turn of the guinea pig cochlea where characteristic frequencies are approximately 4000 Hz. In order to compare IHC responses with rate suppression measured in the auditory nerve, suppressors were introduced that produced little or no response in the hair cell.
Peter Dallos, Mary Ann Cheatham
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The Journal of Laryngology & Otology, 2011
AbstractThe stereocilia of the inner ear are unique cellular structures which correlate anatomically with distinct cochlear functions, including mechanoelectrical transduction, cochlear amplification, adaptation, frequency selectivity and tuning. Their function is impaired by inner ear stressors, by various types of hereditary deafness, syndromic ...
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AbstractThe stereocilia of the inner ear are unique cellular structures which correlate anatomically with distinct cochlear functions, including mechanoelectrical transduction, cochlear amplification, adaptation, frequency selectivity and tuning. Their function is impaired by inner ear stressors, by various types of hereditary deafness, syndromic ...
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Inner hair cell synapse density influences auditory processing
2022AbstractLoss of synapses between spiral ganglion neurons and inner hair cells (IHC synaptopathy), leads to an auditory neuropathy called hidden hearing loss (HHL) characterized by normal auditory thresholds but reduced amplitude of sound-evoked auditory potentials. It has been proposed that synaptopathy and HHL result in poor performance in challenging
Lingchao Ji +6 more
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The Journal of the Acoustical Society of America, 2002
Steady-state evoked potentials were measured from unanesthetized chinchillas both before and after carboplatin-induced selective inner hair cell loss. Recordings were made from both the inferior colliculus (IC) and the auditory cortex (AC). The steady-state potential was measured in the form of the envelope following response (EFR), obtained by ...
Robert Burkard, Sally A. Arnold
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Steady-state evoked potentials were measured from unanesthetized chinchillas both before and after carboplatin-induced selective inner hair cell loss. Recordings were made from both the inferior colliculus (IC) and the auditory cortex (AC). The steady-state potential was measured in the form of the envelope following response (EFR), obtained by ...
Robert Burkard, Sally A. Arnold
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Conditional Tnfaip6-Knockout in Inner Ear Hair Cells Does not Alter Auditory Function
Neuroscience BulletinNoise-induced hearing loss is a worldwide public health issue that is characterized by temporary or permanent changes in hearing sensitivity. This condition is closely linked to inflammatory responses, and interventions targeting the inflammatory gene tumor necrosis factor-alpha (TNFα) are known to mitigate cochlear noise damage. TNFα-induced proteins (
Yue, Qiu +11 more
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Hearing Research, 2002
Thirteen adult chinchillas were anesthetized with ketamine/acepromazine and tungsten electrodes were placed in the right inferior colliculus (IC) and auditory cortex (AC). A reference electrode was implanted in the anterior cranium. Following a recovery period, AC and IC responses to left ear stimulation were obtained from unanesthetized animals ...
Robert Burkard, Yuqing Guo
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Thirteen adult chinchillas were anesthetized with ketamine/acepromazine and tungsten electrodes were placed in the right inferior colliculus (IC) and auditory cortex (AC). A reference electrode was implanted in the anterior cranium. Following a recovery period, AC and IC responses to left ear stimulation were obtained from unanesthetized animals ...
Robert Burkard, Yuqing Guo
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Hearing Research, 2018
Peterson and Heil [Hear. Res., In Press] have argued that the statistics of spontaneous spiking in auditory nerve fibers (ANFs) can be best explained by a model with a limited number of synaptic vesicle docking (release) sites (∼4) and a relatively-long average redocking time (∼16-17 ms) for each of the sites.
Ian C. Bruce +2 more
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Peterson and Heil [Hear. Res., In Press] have argued that the statistics of spontaneous spiking in auditory nerve fibers (ANFs) can be best explained by a model with a limited number of synaptic vesicle docking (release) sites (∼4) and a relatively-long average redocking time (∼16-17 ms) for each of the sites.
Ian C. Bruce +2 more
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Hearing Research, 1980
Intracellular receptor potentials were recorded from inner hair cells in the basal turn of the guinea pig cochlea in response to low frequency tones. These were compared with the cochlear microphonic (CM) recorded from the scala tympani and sound pressure at the tympanic membrance. The CM is symmetrical and behaves as if it responds to basilar membrane
P.M. Sellick, Ian J. Russell
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Intracellular receptor potentials were recorded from inner hair cells in the basal turn of the guinea pig cochlea in response to low frequency tones. These were compared with the cochlear microphonic (CM) recorded from the scala tympani and sound pressure at the tympanic membrance. The CM is symmetrical and behaves as if it responds to basilar membrane
P.M. Sellick, Ian J. Russell
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