Results 291 to 300 of about 10,895,649 (358)

Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells.

Development
Jukic A, Lei Z, Cebul ER, Pinter K, Tadesse Y, Jarysta A, David S, Mosqueda N, Tarchini B, Kindt K.   +9 more
europepmc   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Pimozide Inhibits Type II but Not Type I Hair Cells in Chicken Embryo and Adult Mouse Vestibular Organs. [PDF]

Biomedicines
Giunta R, Cheli G, Rispoli G, Russo G, Masetto S.   +4 more
europepmc   +1 more source

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in zebrafish lateral-line hair cells. [PDF]

iScience
Lee DS, Schrader A, Zou J, Ang WH, Warchol ME, Sheets L.   +5 more
europepmc   +1 more source

BRCA1 Promotes Repair of DNA Damage in Cochlear Hair Cells and Prevents Hearing Loss. [PDF]

J Neurosci
Jiang W, Wang G, Bai F, Hu B, Xu Y, Xu X, Nie G, Zhu WG, Chen F, Pei XH.   +9 more
europepmc   +1 more source

In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells. [PDF]

JCI Insight
O'Connor AP, Amariutei AE, Zanella A, Hool SA, Carlton AJ, Kong F, Saenz-Roldan M, Jeng JY, Lecomte MJ, Johnson SL, Safieddine S, Marcotti W.   +11 more
europepmc   +1 more source

Molecular specializations underlying phenotypic differences in inner ear hair cells of zebrafish and mice. [PDF]

Front Neurol
Giffen KP, Liu H, Yamane KL, Li Y, Chen L, Kramer KL, Zallocchi M, He DZ.   +7 more
europepmc   +1 more source

Conditional Overexpression of Net1 Enhances the Trans-Differentiation of Lgr5⁺ Progenitors into Hair Cells in the Neonatal Mouse Cochlea. [PDF]

Cell Prolif
Lin Y, Zhang Q, Tong W, Wang Y, Wu L, Xiao H, Tang X, Dai M, Ye Z, Chai R, Zhang S.   +10 more
europepmc   +1 more source

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Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

Nature Medicine, 2005
George Cotsarelis
exaly   +2 more sources