Results 271 to 280 of about 228,585 (314)
Some of the next articles are maybe not open access.
Annual Review of Neuroscience, 2000
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
openaire +2 more sources
Hair cells adapt to sustained deflections of the hair bundle via Ca2+dependent negative feedback on the open probability of the mechanosensitive transduction channels. A model posits that adaptation relieves the input to the transduction channels—force applied by elastic tip links between stereocilia—by repositioning the insertions of the links in the
openaire +2 more sources
MECHANISMS OF HAIR CELL TUNING
Annual Review of Physiology, 1999▪ Abstract Mechanosensory hair cells of the vertebrate inner ear contribute to acoustic tuning through feedback processes involving voltage-gated channels in the basolateral membrane and mechanotransduction channels in the apical hair bundle. The specific number and kinetics of calcium-activated (BK) potassium channels determine the resonant ...
R, Fettiplace, P A, Fuchs
openaire +2 more sources
Vesicle Targeting in Hair Cells
Audiology and Neurotology, 2002The mammalian hair cell has two distinct plasma membrane domains separated by tight junctions, the apical domain which contains the stereocilia and the basolateral domain which contains the presynaptic region. Little is known concerning the mechanisms that regulate vesicle trafficking to these two domains.
Robert J, Wenthold +7 more
openaire +2 more sources
Hearing Research, 1990
This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
openaire +3 more sources
This study assessed the contribution of the apical hair cells to hearing. Guinea pigs, chinchillas and monkeys were behaviorally trained using positive reinforcement to respond to pure-tone stimuli. When a stable audiogram had been determined, each subject received one of three experimental treatments: ototoxic drug administration, low-frequency noise ...
Prosen, Cynthia A. +7 more
openaire +3 more sources
Seminars in Cell & Developmental Biology, 2007
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
James M, Waters +2 more
openaire +2 more sources
The increasing use of the hair follicle as a stem cell paradigm is due in part to the complex interplay between epithelial, dermal and other cell types, each with interesting differentiation potential and prospective therapeutic applications. This review focuses on research into the environmental niche, gene expression profiles and plasticity of hair ...
James M, Waters +2 more
openaire +2 more sources
Immunolocalization of myosin Iβ in the hair cell's hair bundle
Cell Motility and the Cytoskeleton, 1998The hair bundle, the hair cell's sensory organelle, transduces acoustical or vestibular stimulation into a change in membrane potential. The actin-based stereociliary processes of the hair bundle contain a number of myosin isoforms that may be important to the bundle's function.
openaire +2 more sources
Cholinergic Inhibition of Hair Cells
2010In the inner ear, the activity of hair cells that transform sound into electrical signals is modulated by a descending efferent innervation from the brain. A major component of this feedback involves cholinergic inhibition of hair cells via an unusual ionic mechanism. It activates rapidly (on the order of milliseconds), but instead of being mediated by
Katz, Eleonora +2 more
openaire +2 more sources
Functional Development of Hair Cells
2003Abstract Embryonic hair cells in chicks and mammals have functional transduction channels and voltage-gated outwardly rectifying potassium (K + ) channels, fast inwardly rectifying channels, and voltage-gated sodium (Na + ) and calcium (Ca 2+ ) channels.
Ruth Anne, Eatock, Karen M, Hurley
openaire +2 more sources
Development and regeneration of hair cells
Acta Oto-Laryngologica, 2007The vertebrate inner ear is derived from the otic placode and undergoes a complicated series of morphogenetic processes to differentiate into an elaborate structure harboring mechanosensory epithelia featuring hair cells, the mechanoreceptors of hearing and balance.
Ozeki, Hidenori +4 more
openaire +2 more sources
Mechanoelectrical Transduction by Hair Cells
Annual Review of Biophysics and Biophysical Chemistry, 1988STRUCTURE AND STIMULATION OF THE HAIR BUNDLE 100 Structure of the Hair Bundle.... ......... .. . . . .... . . . . . . . . . . . . . . . . . . . . . .. . . . . . 100 Mechanical Properties of the Hair Bundle ....... ......... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
J, Howard, W M, Roberts, A J, Hudspeth
openaire +2 more sources