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ybx1 acts upstream of atoh1a to promote the rapid regeneration of hair cells in zebrafish lateral-line neuromasts. [PDF]
PeerJReagor CC, Bravo P, Hudspeth AJ.
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Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells. [PDF]
J Assoc Res OtolaryngolFoo CZ +4 more
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Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects. [PDF]
Proc Natl Acad Sci U S ADewey JB.
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Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells. [PDF]
Hear ResPeineau T +6 more
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Ptgds downregulation protect vestibular hair cells from aminoglycoside-induced vestibulotoxicity. [PDF]
PLoS OneChen C, Zhao Z, Han J, Zhang Y, Nie G.
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Current Opinion in Neurobiology, 1993
Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed.
J T, Corwin, M E, Warchol, M W, Kelley
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Neurobiologists have been challenged by the desire to understand how the highly specialized ultrastructure of the sensory hair cells of the ear develops, how patterns of phenotypically distinct hair cells are formed and regenerate, and how their specific neural connections are formed.
J T, Corwin, M E, Warchol, M W, Kelley
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2019
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Yan, Chen +3 more
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Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In contrast, hair cells in nonmammalian vertebrates such as birds and in the zebrafish lateral line have the ability to regenerate after hair cell loss.
Yan, Chen +3 more
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How hair cells hear: the molecular basis of hair-cell mechanotransduction
Current Opinion in Otolaryngology & Head & Neck Surgery, 2008This review aims to summarize our current knowledge regarding mechanotransduction by hair cells and to highlight unresolved questions.Despite over a quarter of a century of electrophysiological data describing hair-cell mechanotransduction, the molecular basis of this process is just now being revealed.
Kelli R, Phillips +2 more
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The Electrophysiology of Hair Cells
Annual Review of Physiology, 1991Both the hearing and vestibular organs of vertebrates contain cells responsive to miniscule mechanical disturbances. The common element is the hair cell, a sensory cell with a specialized mechanoreceptor at its apical end and with a basolateral membrane designed to shape the receptor potential and control synaptic interaction at its basal pole. The way
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Models of Hair Cell Mechanotransduction
2007Hair cell mechanotransduction is based on a finely tuned machinery residing in the hair bundle, the hair cell's receptive organelle. The machinery consists of a transduction channel, an adaptation motor, the tip link, and many other components that reside in the stereocilia.
Bechstedt, S., Howard, J.
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