Results 81 to 90 of about 735,542 (308)

Oscillation results for second-order half-linear differential equations

Mathematical and Computer Modelling, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Sturm-Liouville Eigenvalue Problems for Half- Linear Ordinary Differential Equations

Rocky Mountain Journal of Mathematics, 2001
The authors consider the half-linear Sturm-Liouville eigenvalue problem \[ \begin{gathered} (p(t)|x'|^{\alpha-1}x')'+\lambda q(t)|x|^{\alpha-1}x=0, \qquad a\leq t\leq b,\tag{HL}\\ Ax(a)-A'x'(a)=0,\qquad Bx(b)+B'x'(b)=0,\end{gathered} \] where \(\alpha>0\) is a constant, \(p,q\) are real-valued continuous functions on \([a,b]\) with \(p(t)>0\) and ...
Kusano, Takaŝi, Naito, Manabu
openaire   +4 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Forced Oscillation of Second-Order Half-Linear Dynamic Equations on Time Scales

Abstract and Applied Analysis, 2010
We will establish a new interval oscillation criterion for second-order half-linear dynamic equation (r(t)[xΔ(t)]α)Δ+p(t)xα(σ(t))=f(t) on a time scale T which is unbounded, which is a extension of the oscillation result for second order linear dynamic ...
Quanwen Lin, Baoguo Jia, Qiru Wang
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The boundary value problem for an ordinary linear half-order differential equation

Қарағанды университетінің хабаршысы. Математика сериясы
This study is devoted to the study of the solution of a boundary value problem for an ordinary linear differential equation of half order with constant coefficients.
N. Aliyev, M. Rasulov, B. Sinsoysal
doaj   +1 more source

Conjugacy Criteria for the Half-Linear Second Order Differential Equation

Rocky Mountain Journal of Mathematics, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Abd-Alla, M.Z., Abu-Risha, M.H.
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source