Results 91 to 100 of about 1,596,954 (307)

Oscillation criteria for second-order half-linear differential equations

Mathematical and Computer Modelling, 1999
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openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A connection between weighted Hardy’s inequality and half-linear dynamic equations

Advances in Difference Equations, 2019
In this paper, we give an affirmative answer to the following question: Is the solvability of some nonlinear dynamic equations on a time scale T $\mathbb{T}$ not only sufficient but in a certain sense also necessary for the validity of some dynamic Hardy-
S. H. Saker, R. R. Mahmoud
doaj   +1 more source

Oscillations of half-linear second order differential equations

Hiroshima Mathematical Journal, 1995
Let \(\varphi:\mathbb{R}\to\mathbb{R}\) be defined by \(\varphi(s)=|s|^{p-2}s\), with \(p>1\) a fixed number. We extend Sturm's comparison theorem of the linear differential equation \[ {\textstyle {\frac{d}{dt}}} [r(t)u'(t)]+ c(t)u(t)=0 \] to the nonlinear differential equation \[ {\textstyle {\frac{d}{dt}}} \{r(t)\varphi(u'(t))\}+ c(t)\varphi(u(t))=0,
Li, Horng Jaan, Yeh, Cheh Chih
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Criteria for oscillation of noncanonical superlinear half-linear dynamic equations

Scientific Reports
This article comes up with criteria to make sure that the solutions to superlinear, half-linear, and noncanonical dynamic equations oscillate in both advanced and delayed cases; these criteria are comparable to the Hille-type and Ohriska-type criteria ...
Taher S. Hassan, Clemente Cesarano, Mouataz Billah Mesmouli, Y. A. Madani, Amir Abdel Menaem, Ayékotan M. J. Tchalla, Belal A. Glalah   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Oscillation constant for modified Euler type half-linear equations

Electronic Journal of Differential Equations, 2015
Applying the modified half-linear Prufer angle, we study oscillation properties of the half-linear differential equation $$ [ r(t) t^{p-1} \Phi(x')]' + \frac{s(t)}{t \log^pt} \Phi(x) = 0, \quad \Phi(x)=|x|^{p-1}\hbox{sgn} x.
Petr Hasil, Michal Vesely
doaj  

On the oscillation of second-order half-linear functional differential equations with mixed neutral term

Journal of Taibah University for Science, 2019
In this article, the authors establish new sufficient conditions for the oscillation of solutions to a class of second-order half-linear functional differential equations with mixed neutral term.
E. Tunç, O. Özdemir
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source