Results 61 to 70 of about 2,027 (126)

Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead

Advanced Genetics, Volume 6, Issue 3, September 2025.
Optogenetics provides up to millisecond scale, cell type‐specific control of biology using light‐sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins and photoactivated enzymes to allosteric switches, surveys broad applications in neuroscience, molecular and cell biology, cardiology, immunology, and ...
Xiao Duan, Mo Zhu, Shiqiang Gao
wiley   +1 more source

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

Advanced Science, Volume 12, Issue 29, August 7, 2025.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu   +8 more
wiley   +1 more source

Comparative Genome Analysis of Three Halobacillus Strains Isolated From Saline Environments Reveal Potential Salt Tolerance and Algicidal Mechanisms

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Following the previous complete genome analysis, this research provides the function of new Halobacillus species. Three strains were identified: Halobacillus shinanisalinarum sp. nov. SSTM10‐2T, Halobacillus salinarum sp. nov. SSBR10‐3T, and Halobacillus amylolyticus sp. nov. SSHM10‐5T.
Saru Gurung, Chang‐Muk Lee, Hang‐Yeon Weon, So‐Ra Han, Tae‐Jin Oh   +4 more
wiley   +1 more source

Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies

Marine Drugs
Halophilic archaea, also termed haloarchaea, are a group of moderate and extreme halophilic microorganisms that constitute the major microbial populations in hypersaline environments.
Micaela Giani, Carmen Pire, Rosa María Martínez-Espinosa   +2 more
doaj   +1 more source

First Insights Into the Biological and Physical–Chemical Diversity of Various Salt Ponds of Trapani, Sicily

Environmental Microbiology Reports, Volume 17, Issue 2, April 2025.
This study unveils the diverse biological and physical–chemical characteristics of the salt ponds in Trapani, Sicily, focusing on microbial community structures and environmental parameters across varying salinities. It highlights unique microbial adaptations and the dynamic interactions shaping this Mediterranean hypersaline ecosystem.
Benvenuta Sonia Cusenza, Giuseppe Scelfo, Gabriella Licata, Fanny Claire Capri, Fabrizio Vicari, Rosa Alduina, Valeria Villanova   +6 more
wiley   +1 more source

Ferric Sulfate and Proline Enhance Heavy-Metal Tolerance of Halophilic/Halotolerant Soil Microorganisms and Their Bioremediation Potential for Spilled-Oil Under Multiple Stresses

Frontiers in Microbiology, 2018
The aim of this study was to explore the heavy-metal resistance and hydrocarbonoclastic potential of microorganisms in a hypersaline soil. For this, hydrocarbonoclastic microorganisms were counted on a mineral medium with oil vapor as a sole carbon ...
Dina M. Al-Mailem, Mohamed Eliyas, Samir S. Radwan   +2 more
doaj   +1 more source

Halolysin SptA, a Serine Protease, Contributes to Growth-Phase Transition of Haloarchaeon Natrinema sp. J7-2, and Its Expression Involves Cooperative Action of Multiple Cis-Regulatory Elements

Frontiers in Microbiology, 2018
Many haloarchaea produce extracellular subtilisin-like proteases (halolysins) during late log phase; however, the physiological function and regulatory mechanism of growth phase-dependent production of halolysins are unknown.
Moran Li, Jing Yin, Sha Mei, Xuhong Wang, Xiao-Feng Tang, Xiao-Feng Tang, Bing Tang, Bing Tang   +7 more
doaj   +1 more source

Advanced Strategies for Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production: PHA Synthase Homologous Overexpression in the Extremophile Haloferax mediterranei

Marine Drugs
Bioplastics such as poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are promising alternatives to conventional plastics. However, the high production cost limits their industrial application.
Alexandra Simica, Yolanda Segovia, Alicia Navarro-Sempere, Rosa María Martínez-Espinosa, Carmen Pire   +4 more
doaj   +1 more source

Rhomboid proteases: key players at the cell surface within haloarchaea

Frontiers in Microbiology
IntroductionRhomboid proteases are intramembrane serine proteases that play a key role in regulating membrane proteins across all domains of life. However, their function in archaea remains poorly understood.
Mariana Inés Costa, Micaela Cerletti, Roberto Alejandro Paggi, Sofia Denise Frecha, Valeria Zoratti, Lucas Leonel Latorre, Rosana Esther De Castro, María Inés Giménez   +7 more
doaj   +1 more source

Recent Advances in Understanding Bio-Compounds from Haloarchaea. [PDF]

J Microbiol Biotechnol
Hwang CY, Seo MJ.
europepmc   +1 more source