Results 91 to 100 of about 68,822 (222)

Comparison of efficacy of haloperidol and olanzapine in the treatment of delirium

Indian Journal of Psychiatry, 2017
Objective: Till date, typical antipsychotic haloperidol is the treatment of choice for delirium. But, due to higher side effects with haloperidol, newer atypical antipsychotics (e.g., olanzapine) are increasingly being used in the treatment of delirious ...
Rajan Jain, Priti Arun, Ajeet Sidana, Atul Sachdev   +3 more
doaj   +1 more source

Major Adverse Cardiac Events with Ondansetron: A Systematic Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 905-915, April 2026.
Evidence base: 170 randomized trials, 23,421 adults, predominantly single‐dose IV ondansetron, mean follow‐up 20 days. Observed outcomes: Major adverse cardiac events were rare, no ventricular arrhythmias or torsades de pointes observed. Conclusion: Ondansetron was not associated with increased mortality or serious cardiac arrhythmias in adult ...
Michael Cristian Garcia, Bhavya Gandhi, Faisal Quadri, Mahnoor Shahab, Kassie Rong, Genevieve Ramnarine, Ishleen Sudan, Sophia Zhang, Michelle Yu, Sara Mojdehi, Lawrence Mbuagbaw, Anne M. Holbrook   +11 more
wiley   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Efficacy and Safety of Remimazolam Compared to Midazolam for Sedation During Endoscopic Ultrasonography: A Single‐Center Retrospective Cohort Study

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Remimazolam is a novel ultra–short‐acting benzodiazepine that may offer advantages over conventional sedatives in endoscopic procedures. Evidence for its use in pancreatobiliary endoscopic ultrasonography (EUS) is limited. We compared the efficacy and safety of remimazolam and midazolam in outpatient pancreatobiliary EUS.
Haruka Toyonaga, Makoto Masaki, Hajime Yamazaki, Arata Oka, Yoshiki Matsuno, Hidetoshi Nakata, Shoji Takayama, Tatsuya Nakagawa, Takuya Takayama, Masahiro Orino, Hironao Matsumoto, Kimi Sumimoto, Masahiro Takeo, Norimasa Fukata, Takeshi Yamashina, Masaaki Shimatani, Makoto Naganuma   +16 more
wiley   +1 more source

Risk of Major Congenital Malformations Associated With the First‐Trimester Exposure to Antipsychotics: A Large Claims Database Study

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with first‐trimester exposure to antipsychotics, using a large claims database in Japan. This retrospective cohort study was based on data from a large claims database in Japan. We used a large claims database from 2010 to 2019.
Ryo Obara, Takamasa Sakai, Tomofumi Ishikawa, Kei Morishita, Motohiko Adomi, Azusa Hara, Saya Kikuchi, Natsuko Kobayashi, Noriyuki Iwama, Genki Shinoda, Aoi Noda, Masatsugu Orui, Mami Ishikuro, Hiroaki Tomita, Nariyasu Mano, Shinichi Kuriyama, Taku Obara   +16 more
wiley   +1 more source

Chronic haloperidol exposure impairs neurodevelopment via Notch1 signaling in human stem cell-derived brain organoids

Scientific Reports
Haloperidol is a typical antipsychotic used to treat schizophrenia and induces dopamine D2 receptor antagonism. Long-term use of haloperidol can reduce brain size in animals and humans; however, the underlying mechanism of this effect remains unclear ...
Hyunsu Kang, Jae-Hyeok Lee, Hana Cho, Ki-Suk Kim   +3 more
doaj   +1 more source

Mortality Predictions Including Pre‐Admission Functional Status in ICU Patients With Delirium—A Substudy of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 4, April 2026.
ABSTRACT Purpose Pre‐admission functional status affects patients' ability to overcome the deteriorating effects of acute critical illness. We aimed to develop a clinical prediction model for 90‐day and 1‐year mortality based on pre‐admission data, including functional status, in adult delirious ICU patients. Methods We included participants randomized
Lone M. Poulsen, Andreas W. Rosen, Nina C. Andersen‐Ranberg, Camilla B. Mortensen, Anders Perner, Stine Estrup, Bodil S. Rasmussen, Ole Mathiesen   +7 more
wiley   +1 more source

Clozapine as add-on medication in the maintenance treatment of bipolar and schizoaffective disorders - A case series [PDF]

, 2002
Atypical neuroleptics are increasingly used in the treatment of bipolar and schizoaffective disorders. Currently, numerous controlled short-term studies are available for clozapine, olanzapine, risperidone or quetiapine, but long-term data are still ...
Amann, B., Dittmann, Sandra, Forsthoff, A., Grunze, Heinz, Hummel, B., Matzner, N.   +5 more
core   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials [PDF]

, 2006
Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive–compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory.
Carey, P, Denys, D, Fineberg, N, Premkumar, P, Seedat, S, Sivakumaran, T, Stein, DJ, Vythilingum, B, Westenberg, H   +8 more
core   +1 more source