Results 81 to 90 of about 31,750 (214)
Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation
MedComm – Oncology, Volume 5, Issue 2, June 2026.The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong +4 more
wiley +1 more source
Learning Outcomes That Maximally Differentiate Psychiatric Treatments
International Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.ABSTRACT Objectives To develop a statistical method that uncovers clinically meaningful differences between active psychiatric treatments, even when traditional rating scales fail to do so. Methods We introduce Supervised Varimax (SV), a novel algorithm that transforms individual items from clinical rating scales into a small set of optimized outcomes ...
Eric V. Strobl, Semmie Kim
wiley +1 more source
International Journal of Methods in Psychiatric Research, Volume 35, Issue 2, June 2026.ABSTRACT Objectives This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia. Methods This cross‐sectional case‐control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous‐treatment ...
Zhengquan Chen +7 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.This graph summarizes bipolar disorder management, showing pharmacological treatments including lithium, valproate, antipsychotics, combination therapy, and emerging agents. It links these treatments to outcomes such as relapse reduction, mortality benefits, and cognitive effects, while highlighting safety issues, poor adherence, pregnancy risks, and ...
Gudisa Bereda
wiley +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.Clopidogrel use was associated with reduced opioid consumption, lower use of other analgesics, and a decreased incidence of hyperactive delirium compared with aspirin in cancer patients receiving chemotherapy, suggesting a potential analgesic effect possibly linked to P2Y12 receptor inhibition.
Hiroaki Abe +9 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.Thirty‐five patients with schizophrenia who received adenine, Ninjin‐yoei‐to, or lithium carbonate were included in the treatment group. Eighty‐one patients with schizophrenia comprised the control group. In the two‐way mixed ANOVA, treatment increased white blood cell and neutrophil counts in patients with schizophrenia, particularly from 2 months ...
Teruyuki Matsuoka, Sumihiro Yamano
wiley +1 more source
Clozapine‐induced diarrhea: A case report and mechanistic overview
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.Abstract Background Clozapine is an atypical antipsychotic that is highly effective in managing treatment‐resistant schizophrenia. However, its use is associated with a wide range of adverse effects, including agranulocytosis, seizures, sedation, and gastrointestinal issues such as constipation, and less commonly, diarrhea. While constipation is a well‐
Shahab Dastmardi, Soha Namazi
wiley +1 more source
BMC AnesthesiologyObjectives To systematically review the evidence about the effect of haloperidol on postoperative delirium in elderly patients. Methods PubMed, Embase, the Cochrane Library and China National Knowledge Infrastructure were used to find concerned studies ...
Meinv Liu +5 more
doaj +1 more source
Blonanserin transdermal patch for treating delirium: A case series
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.In a retrospective case series of 51 patients with delirium treated at a single center between 2020 and 2022, clinical improvement was observed in 84.3% of patients following the use of a blonanserin transdermal patch, often within 1–2 weeks. The patch was mainly selected for patients who had difficulty taking oral medications.
Mari Hemmi +9 more
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.ABSTRACT Introduction Although drug shortages for outpatient chronic conditions commonly occur, population‐level data on how they impact patients' ability to refill prescriptions is scarce. We sought to identify distinct patterns of refill adherence following drug shortages and patient‐ and prescription‐level factors associated with adherence ...
Katie J. Suda +14 more
wiley +1 more source