Results 61 to 70 of about 31,655 (203)

Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection: A Multicentre, Pragmatic, Randomized Trial—Vanguard Results

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background It is unclear whether antibiotics improve outcomes for older adults with delirium who have pyuria or bacteriuria in the absence of other signs or symptoms of a urinary tract infection. Methods Our study is a multicenter, parallel‐group, single‐blinded, non‐inferiority pragmatic randomized trial.
Michael Fralick, Nathan M. Stall, Katarina Zorcic, Christina Reppas‐Rindlisbacher, Eric Kaplovitch, Amy S. Li, Derek R. MacFadden, Daniel Kobewka, Lucas Castellani, Patricia Parsons, Allison McGeer, Janine McCready, Bryant Lim, Emil Hodzic‐Santor, Christopher Kandel, for the A‐DONUT Study Team, Hania Siddiqui, Harshita Chaudhary, Afsaneh Raissi, Tamara Van Bakel, Maureen Taylor, Enoch Choo, Sharrmini Chandrasegaram, Natalie Walde, Irene Amadu, Logan Coccimiglio, Malaz Idris   +26 more
wiley   +1 more source

Chronic haloperidol exposure impairs neurodevelopment via Notch1 signaling in human stem cell-derived brain organoids

Scientific Reports
Haloperidol is a typical antipsychotic used to treat schizophrenia and induces dopamine D2 receptor antagonism. Long-term use of haloperidol can reduce brain size in animals and humans; however, the underlying mechanism of this effect remains unclear ...
Hyunsu Kang, Jae-Hyeok Lee, Hana Cho, Ki-Suk Kim   +3 more
doaj   +1 more source

Triggers, Responses, and Outcomes for Patient Related Violence and/or Aggression Events During Acute Hospitalisation: A Documentary Analysis

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To examine triggers, responses, and outcomes for patient‐related violence and/or aggression events during acute hospitalisation. Design This was a descriptive observational study undertaken at two healthcare organisations. Methods Pre‐existing data were extracted from organisational incident reports and individual medical records during a ...
Debra Kerr, Alison M. Hutchinson, Elisa Ilarda, Louise Alexander, Susan Perlen, Nicole Davies, Trish Mant, Angela Skazlic, Joanna Petrunic, Rachel Mrhar, Adam Searby   +10 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Effectiveness of a Psychiatrist‐Led Clinic for Metabolic Health in Severe Mental Illness: A Retrospective Chart Review Study

Acta Psychiatrica Scandinavica, Volume 154, Issue 1, Page 74-88, July 2026.
ABSTRACT Background Psychotropic medications are associated with serious metabolic adverse effects, which contribute to an increased risk of cardiometabolic comorbidities in patients with severe mental illness (SMI). Several intervention strategies are available to mitigate these metabolic adverse effects; however, data on their utility in real‐world ...
Nicolette Stogios, Femin Prasad, Riddhita De, Kateryna Maksyutynska, Akash PrasannaKumar, Vittal Korann, Tariq Ahmed, Marcos Sanches, Leah Burton, Mohammed A. Alarabi, Tanner Isinger, Michelle Desanti, Rebecca Oliveira, Daphne J. Korczak, Ariel Graff‐Guerrero, Gary Remington, Margaret K. Hahn, Sri Mahavir Agarwal   +17 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Pediatric Wilson Disease in Sudan: A Rare Case, Sudan Conflict and Diagnostic Challenges

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Wilson disease is rarely reported among African children. Wilson disease is due to a mutation in ATP7B on an autosomal recessive pattern, which causes defective copper excretion and copper accumulation in tissues such as liver and brain.
Amjed Abdu Ali Mohammed, Anaheed Alzubair Mohammed HabeebAllah, Sudad salahaldeen Hassan Mohammed, Aprar Kamal Mohammed Ali Almamoon, Mehad Mortada BadrAlden Ahmed, Arafa Mubarak Abotalib Aref, Fatima Bashir Omer Bashir, Tarig Mohamed Nourallah Altegani, Ahmed Alshafei Elmahi Ahmed   +8 more
wiley   +1 more source

Differential Responsiveness to Exercise and Cognitive Remediation in Physical Health in People With Schizophrenia: Results From the CORTEX‐SP Study

European Journal of Sport Science, Volume 26, Issue 6, June 2026.
ABSTRACT Non‐pharmacological interventions, such as exercise and cognitive remediation, have been widely investigated in people with schizophrenia (SZ), showing beneficial effects and supporting their role as complementary approaches to pharmacological treatment.
Mikel Tous‐Espelosin, Nagore Iriarte‐Yoller, Agurne Sampedro, Iker Lasa‐Sagaseta, Cristóbal Pavon, Natalia Ojeda, Pedro Sanchez, Javier Peña, Sara Maldonado‐Martín   +8 more
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source