Results 41 to 50 of about 31,655 (203)

Antipsychotic Drugs Reverse MK801-Inhibited Cell Migration and F-actin Condensation by Modulating the Rho Signaling Pathway in B35 Cells

open access: yesBehavioural Neurology, 2020
Background and Aim. MK801-induced psychotic symptoms and also the Ras homolog family member A (RhoA) expression and cell division control protein 42 (cdc42) mRNA modulation in the rat brain have been investigated.
Yi-Chyan Chen   +2 more
doaj   +1 more source

Critical care delirium: prevention, identification and management: a narrative review

open access: yesAnaesthesia, EarlyView.
Summary Introduction Delirium is a frequent complication of critical illness and remains an important cause of short‐ and long‐term morbidity for patients admitted to ICUs. Delirium is associated with prolonged mechanical ventilation; extended ICU and hospital stay; and longer‐term health issues. Development is associated with patient (e.g.
Stephanie Kieswick, Ben Gibbison
wiley   +1 more source

Comparison of intramuscular haloperidol and other short-acting injectable antipsychotics for management of acute agitation in an adult inpatient psychiatry unit [PDF]

open access: yesMental Health Clinician
Introduction There is no consensus on the optimal antipsychotic for acute agitation. Whereas haloperidol is frequently used and has proven efficacy, second generation antipsychotics show similar efficacy and improved safety and tolerability.
Sarah Gamcsik, PharmD   +1 more
doaj   +1 more source

Effect of 5-HT2A receptor antagonism on levels of D2/3 receptor occupancy and adverse behavioral side-effects induced by haloperidol: a SPECT imaging study in the rat

open access: yesTranslational Psychiatry, 2021
Several studies suggested that 5-HT2A receptor (5-HT2AR) blockade may provide a more favorable efficacy and side-effect profile to antipsychotic treatment.
Stergios Tsartsalis   +4 more
doaj   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen   +3 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander   +5 more
wiley   +1 more source

Rapid tranquilization in a psychiatric emergency room: A naturalistic cohort study in 12 h

open access: yesPsychiatry Research Communications
The purpose of this study was to conduct a naturalistic assessment of the efficacy of four distinct fast tranquilization techniques (intramuscular haloperidol, midazolam, haloperidol plus promethazine, or haloperidol plus midazolam) over a period of 12 h.
Leonardo Baldaçara   +4 more
doaj   +1 more source

What happens after an oral ingestion of haloperidol decanoate? – A case report

open access: yesJornal Brasileiro de Psiquiatria, 2019
Haloperidol decanoate is a first generation antipsychotic drug used to treat patients with schizophrenic disorder who require prolonged parenteral antipsychotic therapy.
João Perestrelo   +2 more
doaj   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira   +3 more
wiley   +1 more source

Intravenous Haloperidol versus Midazolam in Management of Conversion Disorder; a Randomized Clinical Trial

open access: yesArchives of Academic Emergency Medicine, 2018
Introduction: Conversion disorder is a condition in which the patient shows psychological stress in physical ways. This study aimed to compare the effects of haloperidol versus midazolam in patients with conversion disorder. Methods: This double-blind
Mohammadali Jafari   +4 more
doaj   +3 more sources

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