Results 101 to 110 of about 68,822 (222)

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Determination of fluphenazine, related phenothiazine drugs and metabolites by combined high-performance liquid chromatography and radioimmunoassay. [PDF]

, 1981
Antibodies have been produced in rabbits immunized with a fluphenazine succinate-human serum albumin conjugate. By radioimmunoassay it is possible to quantify fluphenazine (FPZ), related phenothiazine drugs and several of their metabolites at the ...
Goldstein, SA, Van Vunakis, H
core  

Seizure as an Atypical Presentation of Myasthenia Gravis: A Rare but Critical Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT A 27‐year‐old male patient with a known case of epilepsy and also recently diagnosed with myasthenia gravis presented with dysphagia, respiratory distress, and seizures. Despite timely intervention, he progressed into septic shock during a myasthenic crisis and succumbed to cardiopulmonary arrest.
Huda Faisal, Chanchan, Karan Chaman Lal, Zahabia Adnan, Shamyl Zehra, MD. Faisal Ahmed   +5 more
wiley   +1 more source

Diabetic Striatopathy in an Elderly Female With Poorly Controlled Type 2 Diabetes: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Diabetic striatopathy (DS) is a rare complication of uncontrolled diabetes mellitus (DM), primarily affecting elderly patients and characterized by choreiform movements with basal ganglia imaging abnormalities. It has a good prognosis and completely resolves with optimal glucose control meeting individualized glycemic goals with a basal‐bolus ...
Ujjwal Kumar Shah, Prabesh Panta, Alok Kumar Jha, Shekhar Jaiswal, Suman Aryal, Prabind Gupta, Shreya Kakshapaty, Chandrashekhar Deuba   +7 more
wiley   +1 more source

Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis—Application in a Real‐World Setting

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 2, March 2026.
ABSTRACT Introduction Genetic factors are thought to play an important role in antipsychotic‐induced weight gain (AIWG). Polygenic risk scores (PRS) could provide a measure of genetic predisposition to antipsychotic drug induced weight gain (AIWG).We conducted a study to examine how a PRS, generated using SNPs, identified from a recent meta‐analysis ...
Adrian Heald, Yasitha Illangasekera, Camila Marcelino Loureiro, Mark Shakespeare, Adam Jameson, Adrian Phillipson, Gavin P. Reynolds, Caroline Dalton   +7 more
wiley   +1 more source

THE INVESTIGATION OF INFLUENCE OF GENETIC PROFILE ON THE EFFICACY AND SAFETY OF HALOPERIDOL IN PATIENTS WITH ALCOHOL DEPENDENCE

Архивъ внутренней медицины, 2016
In case of patients with alcohol addiction haloperidol is used to control the exacerbation of the addiction, but the empirical dose selection of haloperidol often results in adverse side effects.
M. S. Zastrozhin, E. A. Grishina, D. A. Sychev, L. M. Savchenko, E. A. Bryun, M. V. Prudnikova, O. M. Saraeva, V. V. Trofimov   +7 more
doaj   +1 more source

Chronic cocaine enhances release of neuroprotective amino acid taurine: a microdialysis study [PDF]

, 2008
Cocaine inhibits high-affinity neurotransmitter uptake at the presynaptic nerve terminals to increase synaptic levels of dopamine, norepinephrine and serotonin^1^. This increase of synaptic dopamine may cause neurotoxicity^2,3^.
Eitan Freedman, Elena Yablonski-Alter, Eleonora Gashi, Mervan Agovic, Shailesh Banerjee, Theodore Lidsky   +5 more
core   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Haloperidol for Pain Management: A Narrative Review

Pharmaceuticals
The use of haloperidol in pain management has been a topic of interest for several decades. Haloperidol is a widely used antipsychotic medication with unique pharmacologic properties that make it a potential candidate for pain management.
Carlos J. Roldan, Jonathan W. Rowland, Alice L. Ye   +2 more
doaj   +1 more source

Blonanserin versus haloperidol in Japanese patients with schizophrenia: A phase 3, 8‐week, double‐blind, multicenter, randomized controlled study

Neuropsychopharmacology Reports, 2019
Objective This Japanese, multicenter, randomized, double‐blind trial, evaluating the efficacy and safety of blonanserin compared with haloperidol in patients with schizophrenia, was previously published by Murasaki in the Japanese language.
Philip D. Harvey, Hiroshi Nakamura, Mitsukuni Murasaki   +2 more
doaj   +1 more source