Results 21 to 30 of about 61,813 (248)

Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
Importance Results of studies on use of prophylactic haloperidol in critically ill adults are inconclusive, especially in patients at high risk of delirium. Objective To determine whether prophylactic use of haloperidol improves survival among critically
M. Boogaard, A. Slooter, R. Brüggemann, L. Schoonhoven, L. Schoonhoven, L. Schoonhoven, A. Beishuizen, J. Vermeijden, D. Pretorius, J. Koning, K. Simons, P. Dennesen, P. H. Voort, S. Houterman, J. V. D. Hoeven, P. Pickkers, Margaretha C. E. van der Woude, Anna Besselink, L. Hofstra, P. Spronk, W. M. Bergh, D. Donker, Malaika Fuchs, A. Karakus, M. Koeman, Mirella W.F. van Duijnhoven, G. Hannink   +26 more
semanticscholar   +1 more source

A systematic review of the effectiveness and safety of droperidol for pediatric agitation in acute care settings

Academic Emergency Medicine, Volume 29, Issue 12, Page 1466-1474, December 2022., 2022
Abstract Objective Agitation in children in acute care settings poses significant patient and staff safety concerns. While behavioral approaches are central to reducing agitation and oral medications are preferred, parenteral medications are used when necessary to promote safety.
Shannon C. Ramsden, Alba Pergjika, Aron C. Janssen, Sukhraj Mudahar, Andrea Fawcett, John T. Walkup, Jennifer A. Hoffmann   +6 more
wiley   +1 more source

Propionate Protects Haloperidol-Induced Neurite Lesions Mediated by Neuropeptide Y

Frontiers in Neuroscience, 2018
Haloperidol is a commonly used antipsychotic drug for treating schizophrenia. Clinical imaging studies have found that haloperidol can cause volume loss of human brain tissue, which is supported by animal studies showing that haloperidol reduces the ...
Minmin Hu, Minmin Hu, Peng Zheng, Yuanyi Xie, Zehra Boz, Yinghua Yu, Renxian Tang, Alison Jones, Kuiyang Zheng, Xu-Feng Huang   +9 more
doaj   +1 more source

Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care: A Randomized Clinical Trial

JAMA Internal Medicine, 2017
Importance Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care.
M. Agar, P. Lawlor, S. Quinn, B. Draper, G. Caplan, D. Rowett, C. Sanderson, J. Hardy, B. Le, S. Eckermann, N. McCaffrey, Linda Devilee, B. Fazekas, Mark A. Hill, D. Currow   +14 more
semanticscholar   +1 more source

Neuroprotective Effects of Alpha Lipoic Acid on Haloperidol-Induced Oxidative Stress in the Rat Brain

Cell & Bioscience, 2011
Haloperidol is an antipsychotic drug that exerts its' antipsychotic effects by inhibiting dopaminergic neurons. Although the exact pathophysiology of haloperidol extrapyramidal symptoms are not known, the role of reactive oxygen species in inducing ...
Perera Joachim, Tan Joon, Jeevathayaparan S, Chakravarthi Srikumar, Haleagrahara Nagaraja   +4 more
doaj   +1 more source

Delirium‐associated medication in people at risk: A systematic update review, meta‐analyses, and GRADE‐profiles

Acta Psychiatrica Scandinavica, Volume 147, Issue 1, Page 16-42, January 2023., 2023
Abstract Background Drug‐associated delirium is a common but potentially preventable neuropsychiatric syndrome associated with detrimental outcomes. Empirical evidence for delirium‐associated medication is uncertain due to a lack of high‐quality studies.
Michael Reisinger, Eva Z. Reininghaus, Johanna De Biasi, Frederike T. Fellendorf, Daniela Schoberer   +4 more
wiley   +1 more source

Haloperidol mais prometazina para pacientes agitados - uma revisão sistemática Haloperidol plus promethazine for agitated patients - a systematic review

Brazilian Journal of Psychiatry, 2009
OBJETIVO: A tranquilização farmacológica rápida e segura de episódios de agitação/agressividade é muitas vezes inevitável. Esta revisão investiga a efetividade da combinação haloperidol e prometazina intramuscular, muito utilizada no Brasil.
Gisele Huf, Evandro Silva Freire Coutinho, Clive Elliot Adams   +2 more
doaj   +1 more source

Neurodevelopment in school‐aged children after intrauterine exposure to antipsychotics

Acta Psychiatrica Scandinavica, Volume 147, Issue 1, Page 43-53, January 2023., 2023
Abstract Objective Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long‐term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school‐aged children.
Lisanne Schrijver, Thalia K. Robakis, Astrid M. Kamperman, Hilmar Bijma, Adriaan Honig, Inge L. van Kamp, Witte J. G. Hoogendijk, Veerle Bergink, Eline M. P. Poels   +8 more
wiley   +1 more source

A case of delayed-onset multiple oculogyric crisis and torticollis episodes after low dose intramuscular haloperidol in a non-neuroleptic drug overdose setting

Proceedings of Singapore Healthcare, 2022
This report documents a rare case of delayed-onset multiple acute dystonias after treatment with low dose intramuscular (IM) haloperidol lactate injection in a setting of non-neuroleptic drug overdose.
Howard Cai Hao Khoe, Vivian Shi Yin Wong
doaj   +1 more source

Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2017
Importance The use of benzodiazepines to control agitation in delirium in the last days of life is controversial. Objective To compare the effect of lorazepam vs placebo as an adjuvant to haloperidol for persistent agitation in patients with delirium in ...
D. Hui, S. Frisbee-Hume, A. Wilson, S. Dibaj, Thuc Nguyen, M. D. L. De La Cruz, P. Walker, D. Zhukovsky, M. Delgado-Guay, Marieberta Vidal, D. Epner, Akhila Reddy, Kimerson Tanco, Janet L. Williams, Stacy Hall, Diane D. Liu, K. Hess, Sapna Amin, W. Breitbart, E. Bruera   +19 more
semanticscholar   +1 more source