Results 11 to 20 of about 3,121 (204)

Important amino acid residues in the chloride pump halorhodopsin that accelerate ion transport despite no direct interaction with the substrate. [PDF]

J Biol Chem
Zhai Y, Shimosaka A, Tsukamoto T, Kikukawa T.   +3 more
europepmc   +3 more sources

Roles of basic amino acid residues in substrate binding and transport of the light-driven anion pump Synechocystis halorhodopsin (SyHR). [PDF]

J Biol Chem
Nakama M, Noji T, Kojima K, Yoshizawa S, Ishikita H, Sudo Y.   +5 more
europepmc   +2 more sources

Halorhodopsin - Light-driven Cl--pump.

membrane, 1984
Toru Yoshizawa, Tarou Ogurusu
openaire   +3 more sources

Fine Tuning of Calcium Constitutive Entry by Optogenetically-Controlled Membrane Polarization: Impact on Cell Migration

Cells, 2020
Anomalies in constitutive calcium entry (CCE) have been commonly attributed to cell dysfunction in pathological conditions such as cancer. Calcium influxes of this type rely on channels, such as transient receptor potential (TRP) channels, to be ...
Charles-Albert Chapotte-Baldacci, Guénaëlle Lizot, Cyrielle Jajkiewicz, Manuella Lévêque, Aubin Penna, Christophe Magaud, Vincent Thoreau, Patrick Bois, Stéphane Sebille, Aurélien Chatelier   +9 more
doaj   +1 more source

Mutations conferring SO4 2− pumping ability on the cyanobacterial anion pump rhodopsin and the resultant unique features of the mutant

Scientific Reports, 2022
Membrane transport proteins can be divided into two types: those that bind substrates in a resting state and those that do not. In this study, we demonstrate that these types can be converted by mutations through a study of two cyanobacterial anion ...
Yuhei Doi, Jo Watanabe, Ryota Nii, Takashi Tsukamoto, Makoto Demura, Yuki Sudo, Takashi Kikukawa   +6 more
doaj   +1 more source

Optical dissection of neural circuits responsible for Drosophila larval locomotion with halorhodopsin. [PDF]

PLoS ONE, 2011
Halorhodopsin (NpHR), a light-driven microbial chloride pump, enables silencing of neuronal function with superb temporal and spatial resolution. Here, we generated a transgenic line of Drosophila that drives expression of NpHR under control of the Gal4 ...
Kengo Inada, Hiroshi Kohsaka, Etsuko Takasu, Teruyuki Matsunaga, Akinao Nose   +4 more
doaj   +1 more source

Optogenetic inhibition of neurons by internal light production

Frontiers in Behavioral Neuroscience, 2014
Optogenetics is an extremely powerful tool for selective neuronal activation/inhibition and dissection of neural circuits. However, a limitation of in vivo optogenetics is that an animal must be tethered to an optical fiber for delivery of light.
Benjamin eLand, Catherine eBrayton, Kara eFurman, Zoe eLaPalombara, Ralph eDiLeone   +4 more
doaj   +1 more source

Biophysical properties of optogenetic tools and their application for vision restoration approaches.

Frontiers in Systems Neuroscience, 2016
Optogenetics is the use of genetically encoded light-activated proteins to manipulate cells in a minimally invasive way using light. The most prominent example is channelrhodopsin2 (ChR2), which allows the activation of electrically excitable cells via ...
Simon Darius Klapper, Anka Swiersy, Ernst Bamberg, Volker Busskamp   +3 more
doaj   +1 more source

Informational lesions: optical perturbation of spike timing and neural synchrony via microbial opsin gene fusions

Frontiers in Molecular Neuroscience, 2009
Synchronous neural activity occurs throughout the brain in association with normal and pathological brain functions. Despite theoretical work exploring how such neural coordination might facilitate neural computation and be corrupted in disease states ...
Xue Han, Xue Han, Xue Han, Xiaofeng Qian, Xiaofeng Qian, Patrick Stern, Amy Chuong, Edward S Boyden, Edward S Boyden, Edward S Boyden, Edward S Boyden   +10 more
doaj   +1 more source

Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task

Frontiers in Behavioral Neuroscience, 2015
The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST ...
Kathrin eJanitzky, Kathrin eJanitzky, Michael eLippert, Achim eEngelhorn, Jürgen eGoldschmidt, Jürgen eGoldschmidt, Jennifer eTegtmeier, Hans-Jochen eHeinze, Hans-Jochen eHeinze, Hans-Jochen eHeinze, Frank W. Ohl, Frank W. Ohl, Frank W. Ohl, Frank W. Ohl   +13 more
doaj   +1 more source