Unique Cl– pump rhodopsin with close similarity to H+ pump rhodopsin
Biophysics and Physicobiology, 2022 Microbial rhodopsin is a ubiquitous membrane protein in unicellular microorganisms. Similar to animal rhodopsin, this protein consists of seven transmembrane helices and the chromophore retinal.
Takashi Kikukawa
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Optimized photo-stimulation of halorhodopsin for long-term neuronal inhibition
BMC Biology, 2019 Background Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain.
Chuanqiang Zhang +7 more
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Optical control of zebrafish behavior with halorhodopsin [PDF]
Proceedings of the National Academy of Sciences, 2009 Expression of halorhodopsin (NpHR), a light-driven microbial chloride pump, enables optical control of membrane potential and reversible silencing of targeted neurons. We generated transgenic zebrafish expressing enhanced NpHR under control of the Gal4/UAS system.
Arrenberg, A., Del Bene, F., Baier, H.
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Next-generation transgenic mice for optogenetic analysis of neural circuits
Frontiers in Neural Circuits, 2013 Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various ...
Brent eAsrican +51 more
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Keratinocytes can modulate and directly initiate nociceptive responses
eLife, 2015 How thermal, mechanical and chemical stimuli applied to the skin are transduced into signals transmitted by peripheral neurons to the CNS is an area of intense study.
Kyle M Baumbauer +9 more
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Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. [PDF]
PLoS ONE, 2011 Intrastriatal grafts of stem cell-derived dopamine (DA) neurons induce behavioral recovery in animal models of Parkinson's disease (PD), but how they functionally integrate in host neural circuitries is poorly understood.
Jan Tønnesen +8 more
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Photocycle of halorhodopsin from Halobacterium salinarium
Biophysical Journal, 1995 The light-driven chloride pump, halorhodopsin, is a mixture containing all-trans and 13-cis retinal chromophores under both light and dark-adapted conditions and can exist in chloride-free and chloride-binding forms. To describe the photochemical cycle of the all-trans, chloride-binding state that is associated with the transport, and thereby initiate ...
Váró, G. +5 more
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Active Transport of Macrocycles into Micelles Using Molecular Pumps
Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.Artificial molecular pumps attached to polymeric micelles were found capable of transporting charged macrocycles into the micelles. The pumps operate with only modestly reduced pumping efficiency as compared to nonmicellar counterparts, indicating that ring‐threading molecular pumps can transport charged solutes into supramolecular assemblies, akin to ...
James S. W. Seale +17 more
wiley +2 more sources
Calretinin positive neurons form an excitatory amplifier network in the spinal cord dorsal horn
eLife, 2019 Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in sensory processing. The neuronal circuits in this region that underpin sensory perception must be clarified to better understand how dysfunction can lead to ...
Kelly M Smith +13 more
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rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo. [PDF]
PLoS ONE, 2013 Expression of optogenetic tools in surviving inner retinal neurons to impart retinal light sensitivity has been a new strategy for restoring vision after photoreceptor degeneration.
Chaowen Wu +3 more
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