Results 61 to 70 of about 3,121 (204)

Writing the Engram: Epigenetic Mechanisms of Memory Allocation

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Memory allocation refers to the selective recruitment of neurons to engram cells upon memory formation. While previous studies have documented the importance of intrinsic excitability and the transcription factor CREB on memory allocation, epigenetic mechanisms have remained poorly understood. Here, we summarise recent discoveries epigenetic mechanisms
Isabella Tarulli, Rebecca Toscano‐Rivalta, Lisa Watt, Johannes Gräff   +3 more
wiley   +1 more source

Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect

Frontiers in Cellular Neuroscience, 2018
Cortical mechanisms that regulate acute or chronic pain remain poorly understood. The prefrontal cortex (PFC) exerts crucial control of sensory and affective behaviors.
Haocheng Zhou, Haocheng Zhou, Erik Martinez, Harvey H. Lin, Runtao Yang, Jahrane Antonio Dale, Kevin Liu, Dong Huang, Jing Wang, Jing Wang   +9 more
doaj   +1 more source

Resonance Raman study of intermediates of the halorhodopsin photocycle [PDF]

FEBS Letters, 1987
The resonance Raman (RR) study of the retinal protein halorhodopsin (HR578) was extended to two of its photoproducts: HR and HRL 410 RR spectra of both species were recorded in H2O and D2O and compared with the RR spectra of the intermediates L550 and M412 from the bacteriorhodopsin photocycle.
Diller, R., Stockburger, M., Oesterhelt, D., Tittor, J.   +3 more
openaire   +2 more sources

Optogenetic delay of status epilepticus onset in an in vivo rodent epilepsy model.

PLoS ONE, 2013
Epilepsy is a devastating disease, currently treated with medications, surgery or electrical stimulation. None of these approaches is totally effective and our ability to control seizures remains limited and complicated by frequent side effects.
Inna Sukhotinsky, Alexander M Chan, Omar J Ahmed, Vikram R Rao, Viviana Gradinaru, Charu Ramakrishnan, Karl Deisseroth, Ania K Majewska, Sydney S Cash   +8 more
doaj   +1 more source

A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level

Nature Communications
Epilepsy affects 1% of the general population and 30% of patients are resistant to antiepileptic drugs. Although optogenetics is an efficient antiepileptic strategy, the difficulty of illuminating deep brain areas poses translational challenges.
Assunta Merolla, Caterina Michetti, Matteo Moschetta, Francesca Vacca, Lorenzo Ciano, Laura Emionite, Simonetta Astigiano, Alessandra Romei, Simone Horenkamp, Ken Berglund, Robert E. Gross, Fabrizia Cesca, Elisabetta Colombo, Fabio Benfenati   +13 more
doaj   +1 more source

Optical suppression of drug-evoked phasic dopamine release

Frontiers in Neural Circuits, 2014
Brief fluctuations in dopamine concentration (dopamine transients) play a key role in behavior towards rewards, including drugs of abuse. Drug-evoked dopamine transients may result from actions at both dopamine cell bodies and dopamine terminals ...
James Edgar Mccutcheon, James Edgar Mccutcheon, Jackson Jordan Cone, Christopher G Sinon, Samantha A Fortin, Pranish A Kantak, Ilana B Witten, Karl eDeisseroth, Garret D Stuber, Mitchell Franklin Roitman   +9 more
doaj   +1 more source

Implantable Light‐Powered Human Designer Cells for Electrical Energy Generation

Advanced Materials, Volume 37, Issue 45, November 13, 2025.
Inspired by the eel's electric organ, a miniature implantable biohybrid device is developed to generate electricity under light activation. The device utilizes a light‐dependent ion gradient formation that induced by genetically engineered human designer cells that express light‐sensitive membrane ion channels and proton pumps, working in synergy with ...
Shuai Xue, Zhihua Lin, Debasis Maity, Preetam Guha Ray, Mingqi Xie, Martin Fussenegger   +5 more
wiley   +1 more source

Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution.

PLoS ONE, 2007
The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly ...
Xue Han, Edward S Boyden
doaj   +1 more source

Ion-Pumping Microbial Rhodopsins

Frontiers in Molecular Biosciences, 2015
Rhodopsins are light-sensing proteins used in optogenetics. The word rhodopsin originates from the Greek words rhodo and opsis, indicating rose and sight, respectively. Although the classical meaning of rhodopsin is the red-colored pigment in our eyes,
Hideki eKandori
doaj   +1 more source

Review of Multifunctional Neural Probe

Advanced Materials Interfaces, Volume 12, Issue 21, November 10, 2025.
Modern multifunctional neural probes for brain‐machine interfaces extend beyond basic electrical functions to incorporate chemical and optical modalities. This review explores recent advances in multifunctional probes developed for neural signal acquisition and stimulation, highlighting how these innovations enhance the precision of brain activity ...
Ziqi Jia, Yong Kyu Yoon
wiley   +1 more source