Results 71 to 80 of about 3,121 (204)
Advanced Science, Volume 12, Issue 42, November 13, 2025.An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen +9 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 21, Page 5567-5579, November 2025.Transplantation of stem cell‐derived photoreceptors in retinal repair. We summarize methods for differentiating stem cells and describe surgical techniques for transplanting photoreceptor precursors to restore visual function (A). The effectiveness of these techniques is assessed with behavioral (B) and in vitro assays (C) using mouse models that mimic
Darin Zerti +5 more
wiley +1 more source
Electrostatic Influence on Photoisomerization in Bacteriorhodopsin and Halorhodopsin
The Journal of Physical Chemistry B, 2019 Bacteriorhodopsin (bR) and halorhodopsin (hR) are both membrane proteins that transport ions across the cell membrane in halobacteria. Their ion transport function is triggered by photoactivated isomerization of the retinal protonated Schiff base (RPSB) chromophore.
C. Punwong +2 more
openaire +3 more sources
Spatiotemporal control in biomedicine: photoswitchable peptides and foldamers
British Journal of Pharmacology, Volume 182, Issue 19, Page 4458-4465, October 2025.Photopharmacology integrates light‐based technology with pharmacology to achieve precise control over biological processes, offering non‐invasive activation and spatiotemporal regulation of biomolecular activity. Within this field, photoswitchable peptides and foldamers provide a powerful approach in precision medicine, enabling reversible ...
Eszter Erdei +5 more
wiley +1 more source
Optogenetic perturbations reveal the dynamics of an oculomotor integrator
Frontiers in Neural Circuits, 2014 Many neural systems can store short-term information in persistently firing neurons. Such persistent activity is believed to be maintained by recurrent feedback among neurons.
Pedro J Goncalves +4 more
doaj +1 more source
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead
Advanced Genetics, Volume 6, Issue 3, September 2025.Optogenetics provides up to millisecond scale, cell type‐specific control of biology using light‐sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins and photoactivated enzymes to allosteric switches, surveys broad applications in neuroscience, molecular and cell biology, cardiology, immunology, and ...
Xiao Duan, Mo Zhu, Shiqiang Gao
wiley +1 more source
Health Science Reports, Volume 8, Issue 9, September 2025.ABSTRACT Background and Aims Parkinson's disease (PD) is a progressive neurological condition that consists of both motor and non‐motor symptoms that considerably deteriorate the quality of life. Pharmacological treatments, primarily levodopa, have been used to manage PD. However, side effects such as dyskinesias and motor fluctuations frequently limit
Muhammad Shaheer Bin Faheem +6 more
wiley +1 more source
Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex
The Journal of Physiology, Volume 603, Issue 16, Page 4609-4636, 15 August 2025.Abstract figure legend Many studies of cortical circuits use optogenetic activation of inhibitory interneurons to suppress pyramidal cell activity, but after the light is turned off pyramidal cells sometimes show excess spiking, which is called a post‐inhibitory rebound.
Jared T. Shapiro +2 more
wiley +1 more source
PLoS Genetics, 2019 Electrical synapses between neurons, also known as gap junctions, are direct cell membrane channels between adjacent neurons. Gap junctions play a role in the synchronization of neuronal network activity; however, their involvement in cognition has not ...
Wei-Huan Shyu +7 more
doaj +1 more source
Chromophore/protein and chromophore/anion interactions in halorhodopsin
Biophysical Journal, 1988 Halorhodopsin (HR), the light-driven chloride transport pigment of Halobacterium halobium, was bleached and reconstituted with retinal analogues with the pi electron system interrupted at different locations (dihydroretinals). The absorption maxima of the artificial pigments formed with the dihydroretinals are found to be very similar to those of the ...
Lanyi, J.K. +5 more
openaire +2 more sources