Results 51 to 60 of about 52,586 (209)

Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase [PDF]

open access: yesJournal of the Serbian Chemical Society, 2013
The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the halothane/calmodulin([Ca2+]4-CaM) complex, and found that halothane molecules bind in the druggable ...
Juranić Nenad O.   +4 more
doaj   +1 more source

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

open access: yesEuropean Journal of Heart Failure, Volume 27, Issue 12, Page 2671-2690, December 2025.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin   +16 more
wiley   +1 more source

EXPERIMENTAL SIMULATION OF POST-OPERATIVE COGNITIVE DISORDERS IN RATS

open access: yesВестник анестезиологии и реаниматологии, 2018
Goal: to develop the design of the experiment for evaluation of cognitive functions and behavior of rats after some aggressive impact imitating anesthesia and surgery in the clinical practice.
I. V. Belozertseva   +4 more
doaj   +1 more source

The use of low‐dose dexmedetomidine constant rate infusion to stabilise blood glucose in a domestic ferret (Mustela putorius furo) with insulinoma undergoing sevoflurane anaesthesia

open access: yesVeterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract A 5.5‐year‐old, male domestic ferret (Mustela putorius furo) diagnosed with insulinoma was presented for a dental procedure under general anaesthesia. In insulinoma patients, it is essential to avoid hypoglycaemia. In other species, constant rate infusion of dexmedetomidine has been reported to sustain adequate blood glucose by inhibiting ...
Anika R. Schiele   +3 more
wiley   +1 more source

Assessment of occupational exposure of medical personnel to inhalatory anesthetics in Poland

open access: yesMedycyna Pracy, 2014
Objectives: Despite common use of inhalatory anesthetics, such as nitrous oxide (N2O), halothane, sevoflurane, and the like, occupational exposure to these substances in operating theatres was not monitored in Poland until 2006.
Małgorzata Kucharska   +1 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +86 more
wiley   +1 more source

Utilização de alfentanil, sufentanil e fentanil em cães anestesiados com halotano Use of alfentanil, sufentanil and fentanyl in dogs anesthetized with halothane

open access: yesCiência Rural, 1999
Os analgésicos opióides promovem analgesia intensa, possibilitando o emprego de concentrações reduzidas dos anestésicos inalatórios, minimizando assim a depressão cardiovascular que ocorre durante a anestesia.
Denise Tabacchi Fantoni   +4 more
doaj   +1 more source

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

open access: yesExperimental Physiology, Volume 110, Issue 12, Page 1928-1947, December 1, 2025.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi   +9 more
wiley   +1 more source

Effects of ketamine-xylazine and propofol-halothane anesthetic protocols on blood gases and some anesthetic parameters in dogs

open access: yesVeterinary World, 2013
Aim: The anesthetic effects and side effects of ketamine–xylazine and propofol–halothane at four different anesthetics protocol were examined in twenty healthy dogs. Methods: Four treatments were conducted using five dogs in each.
L. M. Alkattan and M. M. Helal
doaj   +1 more source

Global anaesthesia practice using inguinal hernia surgery as a tracer condition: a secondary analysis of an international prospective cohort study

open access: yesAnaesthesia, Volume 80, Issue 11, Page 1343-1351, November 2025.
Summary Introduction Restoration of surgical capacity is essential to post‐COVID‐19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of health systems.
NIHR Global Health Research Group on Environmentally Sustainable Hospitals in Low‐ and Middle‐income Countries   +5007 more
wiley   +1 more source

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