Results 51 to 60 of about 30,433 (209)

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice

Alzheimer's &Dementia, Volume 21, Issue 4, April 2025.
Abstract INTRODUCTION Early episodic memory impairment in Alzheimer's disease (AD) is linked to synaptic dysfunction from amyloid β‐protein oligomers (oAβ), particularly affecting the dentate gyrus mossy fiber‐CA3 pathway. The APPNL‐G‐F mouse model exhibits early deficits in mossy fiber long‐term potentiation (mf‐LTP).
Shan‐Xue Jin, Jean‐Pierre Bellier, Adrienne Wells, Paula Montero LIopis, Praju Vikas Anekal, Jason S. Tresback, Barbara J. Caldarone, Lei Liu, Shaomin Li, Ulf Dettmer, Nagendran Ramalingam, Dennis J. Selkoe   +11 more
wiley   +1 more source

Ethosuximide: Subunit‐ and Gβγ‐dependent blocker and reporter of allosteric changes in GIRK channels

British Journal of Pharmacology, Volume 182, Issue 8, Page 1704-1718, April 2025.
Background and Purpose The antiepileptic drug ethosuximide (ETX) suppresses epileptiform activity in a mouse model of GNB1 syndrome, caused by mutations in Gβ1 protein, likely through the inhibition of G‐protein gated K+ (GIRK) channels. Here, we investigated the mechanism of ETX inhibition (block) of different GIRKs.
Boris Shalomov, Theres Friesacher, Daniel Yakubovich, J. Carlo Combista, Haritha P. Reddy, Shoham Dabbah, Harald Bernsteiner, Eva‐Maria Zangerl‐Plessl, Anna Stary‐Weinzinger, Nathan Dascal   +9 more
wiley   +1 more source

Comparison of Halothane and Propofol effect on blood pressure and heart rate changes in maintenance of anesthesia

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2004
Background and Objective: Propofol is an intravenous anesthetic for induction and maintenance of anesthesia, which its usage is increasing owing to produce a general state of post operative well being, antiemetic effect, rapid onset and recovery.
E Alijan Pour, H Al Reza, M Baradaran, M Najafian Ashrafi, A Bijani   +4 more
doaj  

Impact of a Procedure for Anesthesia on the Postoperative Period in Children Operated on under Extracorporeal Circulation

Общая реаниматология, 2009
Objective: to show that patients’ accelerated activation in the use of combined anesthesia with sevoflurane and fentanyl reduces the incidence of pulmonary complications in young age children after surgery under extracorporeal circulation.
Yu. A. Bakhareva, Z. Z. Nadiradze, A. V. Domansky   +2 more
doaj   +1 more source

On the mechanisms of brain blood flow regulation during hypoxia

The Journal of Physiology, Volume 603, Issue 8, Page 2263-2280, 15 April 2025.
Abstract figure legend Schematic illustration of key hypothesized mechanisms mediating the cerebrovascular response to hypoxia, suggested by the results of studies included in this analysis. Abstract The brain requires an uninterrupted supply of oxygen and nutrients to support the high metabolic needs of billions of nerve cells processing information ...
Alexander Mascarenhas, Alice Braga, Sara Maria Majernikova, Shereen Nizari, Debora Marletta, Shefeeq M. Theparambil, Qadeer Aziz, Nephtali Marina, Alexander V. Gourine   +8 more
wiley   +1 more source

Unwanted Intra-operative Penile Erection During Pediatric Hypospadiasis Repair Comparison of Propofol and Halothane

Urology Journal, 2013
Purpose: To compare the erectile effect of propofol and halothane on unwanted intraoperativepenile erection (UIOPE) during pediatric hypospadiasis repair.Materials and Methods: One hundred and seventeen boys who were in the age range of6 months to 6 ...
Hamid Reza Abbasi, Seyed Soheil Ben Razavi, Mohammad Reza Hajiesmaeili, Shekoufeh Behdad, Mohammad Mehdi Ghiamat, Ahmad Eghbali   +5 more
doaj  

Effects of halothane and isoflurane on uterine muscle relaxation during caesarian section

مجلة كلية الطب, 2013
Background: The use of nitrous oxide- oxygen alone for the maintenance of general anesthesia in obstetrics is associated with an unacceptable incidence of awareness. We have to add inhalational anesthetic drug.
Iyad A. Salman
doaj   +1 more source

Drug‐Induced Liver Injury in Patients With Chronic Liver Disease

Liver International, Volume 45, Issue 3, March 2025.
ABSTRACT Objective Drug‐induced liver injury (DILI) is a global problem and can develop from exposure to prescription or over‐the‐counter medications as well as herbal and dietary supplements. The diagnosis of DILI is clinically challenging, and liver injury can be severe leading to liver failure, death, or liver transplantation.
Marwan Ghabril, Raj Vuppalanchi, Naga Chalasani   +2 more
wiley   +1 more source

Utilização de alfentanil, sufentanil e fentanil em cães anestesiados com halotano Use of alfentanil, sufentanil and fentanyl in dogs anesthetized with halothane

Ciência Rural, 1999
Os analgésicos opióides promovem analgesia intensa, possibilitando o emprego de concentrações reduzidas dos anestésicos inalatórios, minimizando assim a depressão cardiovascular que ocorre durante a anestesia.
Denise Tabacchi Fantoni, Aline Magalhães Ambrosio, Fábio Futema, Elton Rodrigues Migliati, Eunice Yuriko Tamura   +4 more
doaj   +1 more source

Arrhythmia Models for Drug Research: Classification of Antiarrhythmic Drugs

Journal of Pharmacological Sciences, 2007
The aim of this study was to classify antiarrhythmic drugs based on their effectiveness on 6 in vivo arrhythmia models, mainly using dogs. The models were produced by two-stage coronary ligation, digitalis, halothane-adrenaline, programmed electrical ...
Keitaro Hashimoto
doaj