Results 51 to 60 of about 75,245 (304)
Halothane binds to druggable sites in the [Ca2+]4-calmodulin (CaM) complex, but does not inhibit [Ca2+]4-CaM activation of kinase [PDF]
Journal of the Serbian Chemical Society, 2013 The mechanism(s) of volatile anesthetics (VA) are poorly understood. We used high resolution NMR spectroscopy to determine the structure of the halothane/calmodulin([Ca2+]4-CaM) complex, and found that halothane molecules bind in the druggable ...
Juranić Nenad O. +4 more
doaj +1 more source
Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes
Annals of Human Genetics, EarlyView.ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott +3 more
wiley +1 more source
Effect of Midazolam and Halothane on hemodynamic changes in maintenance of anesthesia
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2002 Background and Objective: Midazolam is the only drug of benzodiazepine category that because of its fast effect and least cardiovascular complications is used for induction and maintenance of anesthesia.
F Naziri +3 more
doaj
Equine Veterinary Journal, EarlyView.Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg +4 more
wiley +1 more source
ANESTHETIC, SOME BIOCHEMICAL AND GASES CHANGES DURING THIOPENTAL, PROPOFOL WITH HALOTHANE PROTOCOL IN DOGS UNDERGOING PNEUMOPERITONEUM [PDF]
Basrah Journal of Veterinary Research, 2013 The experiment was carried out in twelve adult healthy ' dogs of both sexes via closed system of anesthesia. The animals were divided into two group's six animals of each. The first group was treated with a protocol of thiopentone sodium I.V. at the dose
Layth al- kattan
doaj +1 more source
Phase transitions in single neurons and neural populations: Critical slowing, anesthesia, and sleep cycles [PDF]
, 2010 The firing of an action potential by a biological neuron represents a dramatic transition from small-scale linear stochastics (subthreshold voltage fluctuations) to gross-scale nonlinear dynamics (birth of a 1-ms voltage spike). In populations of neurons
Sleigh, James W. +3 more
core +2 more sources
POST-HALOTHANE JAUNDICE IN RELATION TO PREVIOUS ADMINISTRATION OF HALOTHANE [PDF]
Survey of Anesthesiology, 1971 The time interval since previous anaesthesia was compared in a surgical population in South Wales and in patients who developed jaundice after halothane. There was a significant difference in the pattern of time interval since previous general anaesthetics in the surgical population and in those patients who developed jaundice after halothane.
William W. Mushin +2 more
openaire +6 more sources
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT Genetic diversity is essential for the sustainability and adaptability of populations, and is thus a central pillar of the agro‐ecological transition. However, within a population, it is inevitable that some amount of genetic variability is lost, and efforts must be made to limit this as much as possible.
Alicia Jacques +2 more
wiley +1 more source
Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct [PDF]
, 1997 We tested whether severe congestive heart failure (CHF), a condition associated with excess free-water retention, is accompanied by altered regulation of the vasopressin-regulated water channel, aquaporin-2 (AQP2), in the renal collecting duct.
Andersen, D. +8 more
core +2 more sources