Results 21 to 30 of about 37,629 (254)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa. [PDF]

PLoS ONE, 2012
A large number of cell wall proteins are encoded in the Neurospora crassa genome. Strains carrying gene deletions of 65 predicted cell wall proteins were characterized.
Abhiram Maddi, Anne Dettman, Ci Fu, Stephan Seiler, Stephen J Free   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

THÀNH PHẦN DINH DƯỠNG CỦA CÁC SẢN PHẨM THUỶ PHÂN TỪ ĐẦU VÀ XƯƠNG CÁ CHẼM (LATES CALCARIFER) BẰNG ENZYME LAVOURZYME

Tạp chí Khoa học Đại học Cần Thơ, 2014
Đầu và xương cá chẽm được thủy phân bằng enzyme Flavourzyme. Bột thuỷ phân protein, dầu cá, bột protein không tan và bột xương cá được tạo thành từ sự thủy phân. Khối lượng và thành phần dinh dưỡng của những sản phẩm được xác định. Kết quả nghiên cứu cho
Nguyễn Thị Mỹ Hương
doaj  

Bisküvi Üretiminde Tam Buğday Unu ve Paçallarının Kullanımı

Journal of Agricultural Sciences, 2014
Bu çalışmada, farklı oranlarda tam buğday unu ikamesi ile bisküvi üretimi amaçlanmıştır. Bu amaçla; Gerek-79 buğday örnekleri, laboratuvar tipi çekiçli değirmende öğütülerek tam buğday unu elde edilmiştir. Tam buğday unları da, altı farklı oranda (% 0,
Mustafa Demir
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

TÌM DẤU CHỈ THỊ PROTEIN TƯƠNG QUAN VỚI HÀM LƯỢNG PROTEIN TRÊN HẠT ĐẬU NÀNH BẰNG PHƯƠNG PHÁP ĐIỆN DI SDS-PAGE

Tạp chí Khoa học Đại học Cần Thơ, 2010
Nhằm tuyển chọn giống đậu nành theo hướng nâng cao hàm lượng protein, đánh giá hàm lượng protein của 166 giống đậu nành bằng phương pháp Kjeldahl và phương pháp điện di protein SDS-PAGE.
Võ Công Thành, Nguyễn Hoàng Tú, Quan Thị Ái Liên   +2 more
doaj  

Karabuğday (Fagopyrum esculentum Moench.) Kepeğinin Yem Kalitesi

Türkiye Tarımsal Araştırmalar Dergisi
Bu çalışmada, karabuğday (Fagopyrum esculentum Moench.) kepeğinin yem kalitesinin belirlenmesi amaçlanmıştır. Çalışmada materyal olarak karabuğdayın Güneş çeşidi kullanılmıştır.
Hakan Yavaş, Serra Nur Öztürk, Ahmet Güneş, Murat Azak, Erdem Gülümser   +4 more
doaj   +1 more source