Results 121 to 130 of about 306,860 (343)

Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source

open access: yesmBio
Hantaviruses are rodent-borne viruses that cause severe disease in infected humans. In the New World, major hantaviruses include Andes virus (ANDV) and Sin Nombre virus (SNV) causing hantavirus pulmonary syndrome.
Rebecca L. Brocato   +10 more
doaj   +1 more source

Photoreactivation of Lethal Damage Induced in Hamster X Xenopus Hybrid Cells and Their Parentals by UV Light [PDF]

open access: yes, 1987
A85 Xenopus cells that exhibited a high level of photoreactivation (PR) and V79B2 hamster cells that exhibited little PR were fused to produce the V79B2 x A85 cell line — a hybrid line which possessed a relatively stable karyotype, with most cells ...
Bohlender, David   +3 more
core   +2 more sources

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely   +14 more
wiley   +1 more source

Effets des acides gras conjugués sur les composantes de la dépense énergétique chez la souris et le hamster

open access: yesOléagineux, Corps gras, Lipides, 2005
We measured the effects of feeding conjugated linoleic acids (CLA) on the various components of energy expenditure in two species known to react differently to CLA treatments, the hamster and the mouse.
Even Patrick   +3 more
doaj   +1 more source

MacDowell-Mansouri gravity and Cartan geometry

open access: yes, 2009
The geometric content of the MacDowell-Mansouri formulation of general relativity is best understood in terms of Cartan geometry. In particular, Cartan geometry gives clear geometric meaning to the MacDowell-Mansouri trick of combining the Levi-Civita ...
Alekseevsky D V   +20 more
core   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk   +4 more
wiley   +1 more source

The golden (Syrian) hamster as a model for the study of reproductive biology: Past, present, and future

open access: yesReproductive Medicine and Biology, 2019
Background The golden (Syrian) hamster (Mesocricetus auratus) is a small rodent that belongs to the Cricetidae family. It has several unique features that are advantageous for the study of reproductive and developmental biology, including a consistent ...
Michiko Hirose, Atsuo Ogura
doaj   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun   +8 more
wiley   +1 more source

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