Results 131 to 140 of about 399,690 (387)

Engineering antibodies with cancer‐associated binding sites

open access: yesBMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian   +4 more
wiley   +1 more source

Synthetic modeling: A cell‐free approach for faster implementation of Raman spectroscopy in cell culture

open access: yesBiotechnology Progress, EarlyView.
Abstract Monitoring cell culture is crucial for gaining a deeper understanding of processes and ensuring the production of safe and high‐quality products. The capability to measure in real time several parameters of interest can be achieved with Raman spectroscopy.
Célia Sanchez   +6 more
wiley   +1 more source

Minimizing batch‐to‐batch variability of a live virus vaccine by process analytical technologies

open access: yesBiotechnology Progress, EarlyView.
Abstract For bioprocesses producing live virus, such as enterovirus Coxsackievirus A21, viral titer (infectivity basis) decay rates can exceed 30% within a day. Consequently, harvest timing is paramount. To optimize titer at harvest, a continuous viral product titer model was generated to elucidate kinetics.
Katherine Forrester   +4 more
wiley   +1 more source

Potassium ion influx and Na+,K+-ATPase activity are required for the hamster sperm acrosome reaction. [PDF]

open access: yes, 1981
The role of a K+ ion influx and Na+,K+-ATPase activity in the hamster sperm acrosome reaction (AR) was examined, using a range of concentrations of K+,K+ ionophores and a Na+,K+-ATPase inhibitor.
Meizel, S, Mrsny, RJ
core  

Use of LC‐MS to characterize host cell protein removal during depth filtration

open access: yesBiotechnology Progress, EarlyView.
Abstract The removal of host cell proteins (HCPs) is crucial in biopharmaceutical production, as residual impurities can impact product safety and efficacy. While a number of studies have demonstrated that depth filtration can provide significant HCP removal, there is little information on its effectiveness in removing specific HCPs.
Liang‐Kai Chu   +3 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu   +5 more
wiley   +1 more source

Characterization of Virus Replication, Pathogenesis, and Cytokine Responses in Syrian Hamsters Inoculated with SARS-CoV-2

open access: yesJournal of Inflammation Research, 2021
Shiu-Ju Yang,1 Ting-Chun Wei,1 Chih-Hao Hsu,1 Sin-Ni Ho,1 Chi-Yun Lai,2 Shiu-Feng Huang,2,3 Yih-Yuan Chen,4 Shih-Jen Liu,1 Guann-Yi Yu,1 Horng-Yunn Dou1,5 1National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes ...
Yang SJ   +9 more
doaj  

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