Results 151 to 160 of about 306,860 (343)

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam   +12 more
wiley   +1 more source

Bypassing Endocytic Barriers: Visualizing Membrane Fusion and Endosomal Escape of Cubic Phase Lipid Nanoparticles (Cubosomes)

open access: yesSmall, EarlyView.
This study uses advanced microscopy techniques, including transmission electron microscopy, scanning electron microscopy (SEM), cryogenic SEM, and live‐cell fluorescence imaging, to investigate lipid cubosome interactions with mammalian cells. It provides the first direct nanoscale evidence of cubosome membrane fusion with plasma and endosomal ...
Sue Lyn Yap   +5 more
wiley   +1 more source

Human skin‐derived micronized acellular dermal matrix modulates angiogenesis to enhance tissue reconstruction

open access: yesVIEW, EarlyView.
Angiogenesis is an essential process in tissue regeneration, as it prevents complications such as necrosis, inflammation, and fibrosis. mADM decellularized by the supercritical carbon dioxide method exhibits high preservation of the extracellular matrix and various growth factors.
Hyo‐Jin Kim   +14 more
wiley   +1 more source

Reduced Mitochondrial Adenine Nucleotide Translocase 1 (ANT1) Correlates With Aging‐Associated Airway Remodeling

open access: yesAging Cell, EarlyView.
Adenine nucleotide translocase 1 (ANT1), a mitochondrial ATP transporter, is decreased in the lung epithelium of aged adults and aged mice correlating to pathogenic airway changes. Loss of ANT1 correlates with increased cellular senescence and changes in COL8A1 in the airway epithelium of the lung.
Roshani Jha   +5 more
wiley   +1 more source

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