Results 161 to 170 of about 115,928 (265)

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Enhanced Sensitivity of a Modified Quaking-Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study. [PDF]

Ann Neurol
Myskiw J, Fox R, Kielich DMS, Lamoureux L, Leonhardt M, Nykvist O, Slota JA, Avery K, Phillipson C, Frost K, Simon S, Appleby BS, Bailey-Elkin BA, Booth SA.   +13 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing. [PDF]

iScience
Kim B, Roenicke R, Roeder PM, Steinberg I, Patamawenu A, Harrison M, Veer FV, Koory E, Xie J, Shofner T, Matsuda K, Wettstein E, Ober E, Cooney C, Kim T, Webber JD, Meeks T, Park C, Burdette T, Georgia S, Readler JM, Vostal AC, Hostal A, Cohen JI, Gagne M, Ziff Z, Richard K, Burnett MR, Maule E, Callier V, Liang J, Kovacikova G, Souter SC, Weiner JA, Douek D, Ackerman ME, Wright PF, Johnson RF, Connors M.   +38 more
europepmc   +1 more source

Biogeographic history of the Late Pleistocene and Holocene European small hamsters (subfamily Cricetinae). [PDF]

Sci Rep
Bujalska B, Golubiński M, Popović D, Berto C, Conard NJ, Lemanik A, Luzi E, Marković Z, Nadachowski A, Popov V, Horáček I, Baca M.   +11 more
europepmc   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection. [PDF]

Chin Med
Wang Y, Tian W, Ye Z, Liao Y, Huang C, Qi D, Wang Y, Chen Y, Zhou Y.   +8 more
europepmc   +1 more source

Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP60

Plant Biotechnology Journal, EarlyView.
Nazgul Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Hong Bi, Stephen J. Streatfield, Rainer Fischer, Vidadi Yusibov   +7 more
wiley   +1 more source

Carbon Footprint of Antibody‐Based Drugs and Biologics Using Hybrid Life Cycle Assessment

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 236-244, July 2026.
Life cycle assessment of monoclonal antibodies. Biological engineering has emerged since the 1980s as one of the most efficient technologies to develop new medicines. The monoclonal antibody platform is the most widely used, representing about 15–20% of drug sales.
Sébastien Taillemite, Martin Fenelon, Marc Scherlinger, Max Piffoux   +3 more
wiley   +1 more source

Single-cell spatiotemporal mapping reveals a spleen-to-lung neutrophil axis in antiviral defense. [PDF]

Immun Inflamm
Yang Z, Cong B, Wang B, Liu S, Liu Y, Ren X, Cao X.   +6 more
europepmc   +1 more source