Results 181 to 190 of about 115,928 (265)

Coronavirus M Protein Hijacks Toll‐Interacting Protein (TOLLIP) to Suppress NF‐κB Signaling and Promote Immune Evasion

MedComm, Volume 7, Issue 7, July 2026.
Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Yabin Zhang, Lu Kang, Yu Zhong, Songjun Shao, Senren Xue, Changliang Liu, Xiaoqi Zheng, Jing‐Wen Lin, Yu Chen, Fengming Luo, Huajing Wan   +10 more
wiley   +1 more source

Transgenic hookworm secretes anti-tetrodotoxin human single chain antibody. [PDF]

Nat Commun
Singh KS, Bharti S, Rosa BA, Bigham M, Uzoechi SC, Choi YJ, Martin JC, Kemper D, Djuranovic SP, Pickering DA, Ryan R, Bracken BK, Bottazzi ME, Carnes EC, Ittiprasert W, Moyle M, Brindley PJ, Loukas A, Djuranovic S, Mitreva M.   +19 more
europepmc   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Osmolality-Independent Impact of Sodium on Glycosylation of an Fc-Fusion Protein and the Hexosamine Biosynthesis Pathway in a Chinese Hamster Ovary Cell Line. [PDF]

Biotechnol J
Reiniger J, Pöttner A, Rosenberger L, Zimmer A.   +3 more
europepmc   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Pathology and viral evolutionary dynamics in a hamster model of persistent SARS-CoV-2 infection. [PDF]

Commun Biol
Wei W, Kuroda M, Liu Y, Iida S, Kandel S, Machovech H, Hirata Y, Suzuki T, Koelle K, Wang Z, Friedrich TC, Kawaoka Y, Halfmann PJ.   +12 more
europepmc   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Computationally guided discovery of Ly6e/LY6E-dependent AAV capsid variants. [PDF]

iScience
Ono H, Fujino S, Sunagawa GA.
europepmc   +1 more source