Results 191 to 200 of about 162,987 (311)

Pangolin-derived sarbecoviruses show attenuated pathogenicity and transmissibility compared with SARS-CoV-2 in human ACE2 transgenic hamsters. [PDF]

mBio
Lin H-F, Jiang R-D, Ji L-N, Zhang J-W, Gong Q-C, Si H-R, Shi Y-S, Lin X-H, Qiu C, Li J-M, Liu M-Q.   +10 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Recent advancements in QuIC-based diagnostic assays for sporadic and inherited prion diseases: focusing on the emerging role of ES-QuIC. [PDF]

Front Neurosci
Fox R, Myskiw J, Bailey-Elkin BA, Booth SA.   +3 more
europepmc   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Stable Constitutive BiP Expression Prolongs Late-Stage GLP-1-Fc Accumulation in CHO Cells. [PDF]

Bioengineering (Basel)
Shaifutdinov RR, Krukov FA, Samok AS, Vorobiev II, Orlova NA.   +4 more
europepmc   +1 more source

A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model. [PDF]

Mol Biomed
Zhou M, Liu X, Miao J, Lin Y, Xiao H, Wu K, Zhang L, Li X, Yang X, Chen L, Ma J, Wang W, Xu N, Li J, Zhu H, Guan Y, Xia N, Cheng T, Yuan L.   +18 more
europepmc   +1 more source

Behind the Curtain of Care. Nurses' Experiences Providing Care to Consumers With Alcohol and Other Drug Issues: A Qualitative Scoping Review

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To scope and synthesise qualitative literature relating to nurses' experiences of providing care to consumers with alcohol and other drug issues and explore how meaning is constructed in practice. Design Scoping review. Methods A scoping review was conducted following Arksey and O'Malley's framework.
Kylie Kearns, Richard Galeano, Louise Alexander   +2 more
wiley   +1 more source

Molecular characterization of Blastocystis sp., Cryptosporidium spp., and Giardia spp. in Eld's deer (Rucervus eldii) and their forest rangers in Hainan, China. [PDF]

Parasit Vectors
Zhang Y, Li J, Xie Z, Han X, Du W, Qiang Y, Ren G, Lei S, Chang Y, Liu X, Lai X, Wang Y, Li X, Zhou Y, Han W, Qi X, Wang H, Lu G.   +17 more
europepmc   +1 more source

Differences in Feeding Management of Pet Rabbits by Owners and Hobby Breeders and Their Impact on Animals' Health: A Survey

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Over the last decades, the population of pet rabbits in Europe has increased significantly, but to date studies into feeding management of these species have been mainly conducted in production animals. This study aimed to evaluate the feeding practices of both pet rabbit owners and hobby breeders in Germany and how these may affect animal ...
Federica Sportelli, Carla Giuditta Vecchiato, Giacomo Biagi, Daniel Brugger, Lisa Sondershaus, Ludovica Maria Eugenia Mammi   +5 more
wiley   +1 more source

HMGA1 is associated with unfavorable outcome and accelerates the aggressiveness of cholangiocarcinoma. [PDF]

SAGE Open Med
Phumphu R, Saisomboon S, Prajumwong P, Waenphimai O, Vaeteewoottacharn K, Wongkham S, Cha'on U, Saengboonmee C, Puapairoj A, Pairojkul C, Kariya R, Okada S, Sawanyawisuth K.   +12 more
europepmc   +1 more source