Results 161 to 170 of about 399,690 (387)

Hypermedia Learning Objects System - On the Way to a Semantic Educational Web

, 2003
While eLearning systems become more and more popular in daily education, available applications lack opportunities to structure, annotate and manage their contents in a high-level fashion.
Engelhardt, Michael, Kárpáti, Andreas, Rack, Torsten, Schmidt, Ivette, Schmidt, Thomas C.   +4 more
core  

The Impact of the Tau Mutation on Reproductive Function in the Golden Hamster [PDF]

, 1995
The tau mutation affects the circadian system of the golden hamster primarily by decreasing the period of the activity cycle from 24 to 20 hours. To study the effect of this mutation on reproductive function in the golden hamster, 3 experiments have been
Thomasson, Eliza Leake
core   +1 more source

Exploration of Fluorinated Pyrazolidine‐3,5‐Diones for Positron Emission Tomography Imaging of the P2Y12 Receptor in the Central Nervous System

ChemMedChem, EarlyView.
Fluorinated pyrazolidine‐3,5‐dione derivatives are developed with the aim to find a positron emission tomography (PET) tracer candidate for imaging of the P2Y12 receptor. All compounds show nanomolar affinity. One compound is radiolabeled with 18F and used in PET imaging studies, revealing rapid metabolism and limited brain uptake.
E. Johanna L. Stéen, Anne van der Schatte Olivier, Berend van der Wildt, Pedro Pereira, Khaled Alkayal, Leopoldo J. Gabella Carena, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Barbara A. Zarzycka, Iwan J. P. de Esch, Albert D. Windhorst   +11 more
wiley   +1 more source

Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source

mBio
Hantaviruses are rodent-borne viruses that cause severe disease in infected humans. In the New World, major hantaviruses include Andes virus (ANDV) and Sin Nombre virus (SNV) causing hantavirus pulmonary syndrome.
Rebecca L. Brocato, Hua Wu, Steven A. Kwilas, Lucia M. Principe, Matthew Josleyn, Joshua Shamblin, Padmanabh Chivukula, Christoph Bausch, Thomas Luke, Eddie J. Sullivan, Jay W. Hooper   +10 more
doaj   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

The Vertebral Column and Epaxial Muscles of the Golden Hamster.

, 1959
Mahabad Abdalaziz Salih
openalex   +2 more sources

HISTOCHEMICAL DEMONSTRATION OF NORADRENALINE IN THE ADRENAL MEDULLA OF THE HAMSTER [PDF]

, 1956
Olavi Eränkö
openalex   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

GONADAL INFLUENCES ON SURVIVAL AFTER ADRENAL-ECTOMY IN THE GOLDEN HAMSTER [PDF]

, 1951
Julian G. Snyder, Leland C. Wyman
openalex   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source