Results 221 to 230 of about 162,987 (311)

LLM‐Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3175-3182, November 2026.
ABSTRACT Mechanistic models of Chinese Hamster Ovary (CHO) cell cultures are essential for efficient bioprocess development and control, yet parameter estimation remains a critical challenge in model calibration. As model complexity increases, the number of parameters grows and their values become highly system‐specific due to biological variability ...
Han Bit Kim, Janghan Lee, Seo‐Yeon Kim, Jihoon Kim, Moo Sun Hong   +4 more
wiley   +1 more source

Adrenocortical Adenocarcinoma in a Syrian Golden Hamster (Mesocricetus auratus) With Suspected Hyperadrenocorticism. [PDF]

Vet Med Sci
Billaux MF, Vieu S, Lecomte A, Cuvelier M, Rohel M, Abadie J, Soetart N.   +6 more
europepmc   +1 more source

Production of the High Value Pharmaceutical Target, Human Granulocyte‐Colony Stimulating Factor, in Nicotiana benthamiana Is Improved by Co‐Expression of the Transcriptional Regulator of the Unfolded Protein Response, bZIP60

Plant Biotechnology Journal, EarlyView.
Nazgul Wagner, Konstantin Musiychuk, Stephen Tottey, Jukka Kervinen, Hong Bi, Stephen J. Streatfield, Rainer Fischer, Vidadi Yusibov   +7 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

High Cell Density Cultivation of HEK293 Cells Using a 2L Membrane‐Stirred Bioreactor

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3165-3174, November 2026.
ABSTRACT The use of perfusion systems for the continuous cultivation of animal cells at high cell density (HCD) for the production of recombinant proteins, viruses, and viral vectors has many advantages. Besides an enhancement of volumetric productivity and high cell viability, the product quality can be improved through a steady‐state environment ...
Lennart Jacobtorweihe, Yasemin van Heuvel, Kathrina Scheiermann, Patrick Bongartz, Yvonne Genzel, Udo Reichl   +5 more
wiley   +1 more source

E-cigarette exposure triggers distal lung cell injury, persistent lung stress response, and antiviral immune suppression. [PDF]

JCI Insight
Rivera TC, Schweitzer KS, Cornell C, Nall J, Egersdorf N, Moeder C, Cooney RA, Vladar EK, Groshong SD, Downey GP, Bridges JP, Bowen R, Chu HW, Petrache I.   +13 more
europepmc   +1 more source

Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy

Muscle &Nerve, Volume 74, Issue 5, Page 1456-1470, November 2026.
ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler, Brian J. Paleo, Mackenzie N. Roth, Kara E. Bradley, Megan N. Winkler, Wakako Yoshioka, Ichizo Nishino, Christoph Lepper, Kelly E. Crowe   +8 more
wiley   +1 more source

Serological Evidence of Schmallenberg Virus Exposure in Ruminant Abortion Cases from Selected Regions of Iran: A Virus Neutralization Test‐Based Study

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Neutralizing antibodies against Schmallenberg virus (SBV) were detected by the virus neutralization test in cattle and sheep with a history of abortion from three selected regions of Iran, providing evidence of prior SBV exposure and highlighting the need for further studies on its epidemiology and circulation.
Mohammad Kiani, Ali Asghar Moghaddam, Mohsen Lotfi, Peyman Rahimi Feyli   +3 more
wiley   +1 more source

Transstadial and transovarial perpetuations of Borrelia venezuelensis in Ornithodoros rudis, with demonstration of vector competence. [PDF]

Exp Appl Acarol
Jorge FR, de Oliveira GMB, Silito IS, Martins MP, Muñoz-Leal S, Labruna MB.   +5 more
europepmc   +1 more source

Neglected but Not Harmless: Characterising Nonantibiotic Antimicrobial Use in Small Animal Practices in Colombia

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Widely used but poorly documented, nonantibiotic antimicrobials represent an overlooked gap in veterinary practice. Frequent prescribing alongside suboptimal dosing and incomplete records underscores the need to formally include NAAs in antimicrobial stewardship and One Health surveillance efforts.
Nathalia M Correa‐Valencia, Susana Arango‐Arcila, Nicolle Kamel Mendoza, Diego Alejandro Sierra‐Zapata, Victoria A. Guzmán‐Mejía, Alejandra Carmona Ramírez, Juan Gonzalo Restrepo Salazar   +6 more
wiley   +1 more source