Results 71 to 80 of about 24,468 (261)

Dangerous Liaisons? Governments, companies and Internet governance

Internet Policy Review, 2013
Private actors in the information technology sector are currently playing an increasingly important role in content mediation, as well as in regulation of online forms of expression, with implications for both internet rights and economic freedom.
Francesca Musiani
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Canine Trainers in Russian National Guard: Professional and Personal Qualities during Training

СибСкрипт
Professional qualities and personality traits affect the efficiency of canine team in the Russian National Guard during routine service and military operations.
Tatyana P. Skripkina, Elena A. Kusakina
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Affective Implications of Human–Animal Relationship on Pig Welfare: Integrating Non-Linear Heart Rate Variability Measures

Animals
The human–animal relationship is crucial for animal welfare. Gentle handling enhances pigs’ comfort while rough handling causes fear and stress. This study examined how different human–animal relationship qualities affect the behavior and heart rate ...
Javiera Calderón-Amor, Belén Zuleta, Maria Camila Ceballos, Daniel Cartes, Christopher J. Byrd, Benjamin Lecorps, Rocío Palomo, Sergio A. Guzmán-Pino, Daniela Siel, Daniela Luna   +9 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Basic principals of the tiltrotors flight control system architecture and algorithms

Научный вестник МГТУ ГА
This study describes the main structure and algorithm development principles of flight control systems for tiltrotor aircraft using the example of rotary-wing aircraft V-22 Osprey and AW609.
M. I. Myasnikov, I. R. Ilyin
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Crises and Electoral Accountability: How Do Individual Characteristics of Crises Affect Performance and Responsibility Evaluations among Voters?

Government and Opposition
How do voters react to the individual characteristics of crises following events such as pandemics or floods? In the aftermath of crises following such events, governments may find they are sanctioned by voters, because the crises can provide voters with
Jan Berz
doaj   +1 more source