Results 51 to 60 of about 364,270 (312)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Prediction of pilot induced oscillations [PDF]
INCAS Bulletin, 2011 An important problem in the design of flight-control systems for aircraft under pilotedcontrol is the determination of handling qualities and pilot-induced oscillations (PIO) tendencieswhen significant nonlinearities exist in the vehicle description. The
Valentin PANĂ
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Managing non‐functional requirements in agile software development
IET Software, 2022 Non‐functional requirements define qualities of the software system that ensure effectiveness while embedding any constraints and restrictions on the design.
Scarlet Rahy, Julian M. Bass
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Demonstrating NISQ era challenges in algorithm design on IBM’s 20 qubit quantum computer
AIP Advances, 2020 As superconducting qubits continue to advance technologically, the realization of quantum algorithms from theoretical abstraction to physical implementation requires knowledge of both quantum circuit construction as well as hardware limitations.
Daniel Koch +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Exploratory piloted simulator study of the effects of winglets on handling qualities of a representative agricultural airplane [PDF]
The effects on handling qualities of adding winglets to a representative agricultural aircraft configuration during swath-run maneuvering were evaluated.
Brown, P. W., Ogburn, M. E.
core +1 more source
Robust control of longitudinal flight with handling qualities constraints [PDF]
, 2007 Classical flight control systems are still widely used in industry because of acquired experience and good understanding of their structure. Nevertheless, with more stringent constraints, it becomes difficult to easily fulfill all the criteria with ...
Akhrif, Ouassima +3 more
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