Results 61 to 70 of about 364,270 (312)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Flight evaluation of advanced control systems and displays on a general aviation airplane [PDF]

open access: yes
A flight-test program was conducted to determine the effect of advanced flight control systems and displays on the handling qualities of a light twin-engined airplane.
Barber, M. R.   +3 more
core   +1 more source

Validation and Verification of Aircraft Control Software for Control Improvement [PDF]

open access: yes, 2007
Validation and Verification are important processes used to ensure software safety and reliability. The Cooper-Harper Aircraft Handling Qualities Rating is one of the techniques developed and used by NASA researchers to verify and validate control ...
Pham, Thien-Anh
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Handling Quality of Woven Fabrics

open access: yesJournal of the Textile Machinary Society, 1961
目的 織物のハンドリングをあらわす特性として, 硬さ, 厚さを選び, これらが人の感覚にどのように感ずるかを調べ合せて物理的特性との関連性を考察し, 織物のハンドリングを評価するための基礎資料をうる.成果濃度のわずかに異なる薄のり液でのり付した綿ブロードについて官能検査によって硬さ, 厚さについて実験した結果を解析してつぎの結果をえた.(1) 硬さのようなわかりやすい特性については判断は比較的よく一致する.(2) 官能による判定は他の特性に大きく影響されるものがある.本実験では厚さが硬さによって左右される結果となっているように, ハンドリングの評価には判定を誤まる要素が多くあると考えられる.(3) 本実験では硬さはハートループおよびカンチレバと比較的一致しているが ...
H. Nakazato, I. Kageyama
openaire   +2 more sources

Rotorcraft handling-qualities design criteria development [PDF]

open access: yes
Joint NASA/Army efforts at the Ames Research Center to develop rotorcraft handling-qualities design criteria began in earnest in 1975. Notable results were the UH-1H VSTOLAND variable stability helicopter, the VFA-2 camera-and-terrain-board simulator ...
Aiken, Edwin W.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

QUALITY CHARACTERISTICS OF BUFFALO CHEEK MEAT [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2012
A study was undertaken to determine the physicochemical and microbiological qualities of fresh buffalo cheek meat. The results of this study characterise buffalo cheek meat as having relatively higher pH and lower TBA no. and cooking loss.
V. N. Vasudevan, V. Venkataramanujam
doaj  

Pilot evaluation of sailplane handling qualities [PDF]

open access: yes
The evaluation sailplanes were found generally deficient in the area of cockpit layout. The pilots indicated general dissatisfaction with high pitch sensitivity especially when coupled with inertially induced stick forces.
Bennett, A. G., Jr.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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