Abstract Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast.
Christina Princk +13 more
wiley +1 more source
Delayed angiopoietin‐2 blockade reduces influenza‐induced lung injury and improves survival in mice
Angiopoietin‐2 (Ang‐2) is a key prognostic marker and potential mediator of Acute respiratory distress syndrome, yet it is unknown whether inhibiting Ang‐2 signaling at its receptor Tie‐2 can reduce viral lung injury after it begins. Here we demonstrate that delayed antagonism of Ang‐2 in mice with severe influenza pneumonia improves survival, gas ...
Jeffrey E. Gotts +9 more
wiley +1 more source
Hemodynamic and Pulmonary Permeability Characterization of Hantavirus Cardiopulmonary Syndrome by Transpulmonary Thermodilution. [PDF]
Hantavirus cardiopulmonary syndrome (HCPS) is characterized by capillary leak, pulmonary edema (PE), and shock, which leads to death in up to 40% of patients. Treatment is supportive, including mechanical ventilation (MV) and extracorporeal membrane oxygenation (ECMO).
López R +6 more
europepmc +5 more sources
Hantavirus cardiopulmonary syndrome successfully treated with high-volume hemofiltration. [PDF]
Hantavirus cardiopulmonary syndrome has a high mortality rate, and early connection to extracorporeal membrane oxygenation has been suggested to improve outcomes. We report the case of a patient with demonstrated Hantavirus cardiopulmonary syndrome and refractory shock who fulfilled the criteria for extracorporeal membrane oxygenation and responded ...
Bugedo G +4 more
europepmc +4 more sources
Drotrecogin Alpha (Activated) in Two Patients with the Hantavirus Cardiopulmonary Syndrome [PDF]
Hantavirus cardiopulmonary syndrome (HCPS) is associated with rapid cardiopulmonary collapse from endothelial injury, resulting in massive capillary leak, shock and severe hypoxemic respiratory failure. To date, treatment remains supportive and includes mechanical ventilation, vasopressors and extracorporeal membrane oxygenation, with mortality ...
Robert C McDermid +3 more
core +6 more sources
Microbiological and epidemiological review of Hantavirus: A Review
Hantaviruses are rodent viruses that have a world-wide distribution. Rodents and insectivores act as asymptomatic, chronic, persistently infected carrier hosts, whereas humans are dead end hosts and may exhibit symptoms after an incubation period of ...
Hardi Marif, Kwestan Ali
doaj +1 more source
Humoral Immune Responses in the Hantavirus Cardiopulmonary Syndrome [PDF]
The immunologic responses that mediate viral clearance of and recovery from hantavirus cardiopulmonary syndrome (HCPS) due to Sin Nombre (SN) virus are unknown. Serial serum samples from 26 patients with acute SN virus infection were tested for IgG, IgA, and IgM reactivity to recombinant viral nucleocapsid (N) and glycoprotein G1 antigens by a novel ...
M, Bharadwaj +4 more
openaire +2 more sources
Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality [PDF]
To determine the relative frequency and prognosis value of proteinuria in hantavirus cardiopulmonary syndrome (HCPS) due to Andes virus.This observational analytical study prospectively obtained data from patients admitted to 12 health centers in nine Chilean cities between 2001 and 2018.
Lopez, Rene +7 more
openaire +4 more sources
INTRODUCTION: Rodent-borne hantaviruses cause severe human diseases. We completed a serological survey of hantavirus infection in rural inhabitants of Turvo County, in the southern State of Santa Catarina, Brazil, in which seropositivity for hantavirus ...
Gregório Wrublevski Pereira +7 more
doaj +1 more source
Pulmonary and cardiovascular syndrome due to hantavirus: clinical aspects of an emerging disease in southeastern Brazil [PDF]
A síndrome pulmonar e cardiovascular por hantavírus é doença causada pela aspiração de aerossóis dos dejetos de roedores silvestres contaminados por vírus da família Bunyaviridae.
BADRA, Soraya Jabur +6 more
core +2 more sources

