Abstract Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast.
Christina Princk +13 more
wiley +1 more source
Delayed angiopoietin‐2 blockade reduces influenza‐induced lung injury and improves survival in mice
Angiopoietin‐2 (Ang‐2) is a key prognostic marker and potential mediator of Acute respiratory distress syndrome, yet it is unknown whether inhibiting Ang‐2 signaling at its receptor Tie‐2 can reduce viral lung injury after it begins. Here we demonstrate that delayed antagonism of Ang‐2 in mice with severe influenza pneumonia improves survival, gas ...
Jeffrey E. Gotts +9 more
wiley +1 more source
Hantavirus cardiopulmonary syndrome successfully treated with high-volume hemofiltration. [PDF]
Hantavirus cardiopulmonary syndrome has a high mortality rate, and early connection to extracorporeal membrane oxygenation has been suggested to improve outcomes. We report the case of a patient with demonstrated Hantavirus cardiopulmonary syndrome and refractory shock who fulfilled the criteria for extracorporeal membrane oxygenation and responded ...
Bugedo G +4 more
europepmc +4 more sources
High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial. [PDF]
Vial PA +15 more
europepmc +2 more sources
Humoral Immune Responses in the Hantavirus Cardiopulmonary Syndrome [PDF]
The immunologic responses that mediate viral clearance of and recovery from hantavirus cardiopulmonary syndrome (HCPS) due to Sin Nombre (SN) virus are unknown. Serial serum samples from 26 patients with acute SN virus infection were tested for IgG, IgA, and IgM reactivity to recombinant viral nucleocapsid (N) and glycoprotein G1 antigens by a novel ...
M, Bharadwaj +4 more
openaire +2 more sources
Drotrecogin Alpha (Activated) in Two Patients with the Hantavirus Cardiopulmonary Syndrome [PDF]
Hantavirus cardiopulmonary syndrome (HCPS) is associated with rapid cardiopulmonary collapse from endothelial injury, resulting in massive capillary leak, shock and severe hypoxemic respiratory failure. To date, treatment remains supportive and includes mechanical ventilation, vasopressors and extracorporeal membrane oxygenation, with mortality ...
Robert C McDermid +3 more
core +6 more sources
Extracorporeal membrane oxygenation for the treatment of severe refractory hantavirus cardiopulmonary syndrome. [PDF]
A previously healthy 22-year-old man presented to a community hospital with diarrhea, vomiting, and a fever of 40°C that had lasted for two days. He was admitted to the intensive care unit. Initially, the patient’s cardiopulmonary findings were normal.
Yao H, McDonald EG.
europepmc +4 more sources
Potential renal sequelae in survivors of hantavirus cardiopulmonary syndrome. [PDF]
Although other hantaviruses are associated with renal manifestations, hantavirus cardiopulmonary syndrome (HCPS) has not been associated with such sequelae. The HCPS survivors were prospectively evaluated for renal complications. Subjects underwent yearly evaluation, laboratory studies, and 24-hour urine collection. Thirty subjects were evaluated after
Pergam SA +5 more
europepmc +4 more sources
Vulnerability of Brazilian municipalities to hantavirus infections based on multi‑criteria decision analysis [PDF]
Background: Hantavirus infection is an emerging zoonosis transmitted by wild rodents. In Brazil, high case-fatality rates among humans infected with hantavirus are of serious concern to public health authorities.
A Moffett +40 more
core +2 more sources
Hantavirus cardiopulmonary syndrome: a report of two cases [PDF]
Infection with hantavirus, from the family Bunyaviridae, causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas. This highly lethal anthropozoonosis afflicts preferentially individuals in rural areas and is transmitted by aerosol of excreta from infected wild rodents.
Moreli, Marcos Lazaro +6 more
openaire +4 more sources

