Results 61 to 70 of about 3,537 (199)

Infectious Complications During Early Treatment of Childhood Acute Lymphoblastic Leukemia—A Comparison Between the ALLTogether and NOPHO ALL‐2008 Protocols

Pediatric Blood &Cancer, Volume 73, Issue 1, January 2026.
ABSTRACT Introduction Infection remains the most common treatment‐related toxicity of childhood ALL, emphasizing the need to identify patients at risk and to tailor treatment strategies accordingly. Aims The primary aim was to compare infectious toxicity during early treatment for childhood ALL following the ALLTogether and NOPHO ALL‐2008 (ALL‐2008 ...
Hannah van Bunningen, Johannes Fermér, Arja Harila, Susanna Ranta, Isabella Donnér, Anne Wretman, Hartmut Vogt, Anna Sällfors Holmqvist, Anders Valind, Ludvig Henriksson, Jonas Abrahamsson, Magnus Borssén, Anna Nilsson, Mats Heyman   +13 more
wiley   +1 more source

The Overlooked Threat of Global Warming on Elasmobranch Fertility

Fish and Fisheries, Volume 27, Issue 1, Page 41-55, January 2026.
ABSTRACT Climate change is increasingly recognised as a critical threat to global biodiversity, yet its impacts on reproductive processes remain poorly understood in many marine taxa. Elasmobranchs (sharks, skates and rays) represent a particularly vulnerable group due to their peculiar life histories, low fecundity, and diverse reproductive modes.
Noémie Coulon, Eric Feunteun, Alexandre Carpentier, Anne Lizé   +3 more
wiley   +1 more source

Case report: Germline CHEK2 mutation is associated with a giant cell glioblastoma

Frontiers in Oncology
Giant cell glioblastoma often exhibits genome instability and is frequently associated with mutations in genes involved in DNA repair pathways including TP53 and DNA mismatch repair genes.
Yongfeng Bi, Dong Wan, Dong Wan, Si Chen, Si Chen, Huafei Chen, Huafei Chen, Lingchuan Guo, Lingchuan Guo, Xiaoshun He, Rong Rong, Jinyuan Xiao, Wei Gao, Sheng Xiao   +13 more
doaj   +1 more source

Haplotype Construction Using Embryos as Probands of the Pathogenic Variations in EXT1, CUL3, and HBA

Human Mutation, Volume 2026, Issue 1, 2026.
Preimplantation genetic testing (PGT) represents a crucial strategy in the prevention of monogenic disorders, ensuring that only embryos free from these genetic conditions are implanted during assisted reproductive technologies. By analyzing the type of haplotypes of the variation of the probands or the carriers, we can significantly enhance the ...
Defeng Shu, Yi Liu, Xiaoli Wang, Tao Liang, Zubo Wu, Priya Gusain   +5 more
wiley   +1 more source

TAF15::ZNF384 Mixed Phenotype Acute Leukemia With Complex Karyotype: Case Report With B‐ALL Induction, Blinatumomab Bridging to Allogeneic Transplant and Literature Review

Clinical Case Reports, Volume 13, Issue 11, November 2025.
TAF15::ZNF384 mixed phenotype acute leukemia with complex karyotype: Case report with B‐ALL Induction, blinatumomab bridging to allogenic transplant and literature review. ABSTRACT CD10, CD19 and MPO in one flow cytometry tube facilitated distinguishing B‐cell acute lymphoblastic leukemia with dim expression of MPO versus B/myeloid mixed phenotype ...
Sarah Blain, Brianna Empringham, Talal Mahdi, Benjamin D. Hedley, Jean McGowan‐Jordan, Ruth Padmore   +5 more
wiley   +1 more source

Optimization and Evaluation of the bestRAD Sequencing Approach: Towards Ascertainment of the Invasion Routes of the Oriental Fruit Fly, Bactrocera dorsalis

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT The bestRAD technique is a reduced genome representation approach with high‐capacity sample multiplexing and physical isolation of biotin‐labelled target DNA fragments using streptavidin beads, which should reduce total cost and genotyping errors. While we here formalise the relevance of this approach within the HTS landscape, our foremost aim
Emeline Charbonnel, Laure Benoit, Sabine Nidelet, Enrique Ortega‐Abboud, Bernhard Gschloessl, Raphaël Leblois, David Ouvrard, Marie‐Pierre Chapuis   +7 more
wiley   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, Volume 58, Issue 11, November 2025.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Integrating Population Genomics and Historical Occurrence Data to Assess the Impact of Land‐Use Changes on Centris Oil Bees in the Brazilian Cerrado

Molecular Ecology, Volume 34, Issue 22, November 2025.
ABSTRACT Habitat loss and fragmentation (HLF) are among the major drivers of bee decline, yet closely related species often show contrasting responses depending on their ecological and demographic traits. The Brazilian Cerrado biodiversity hotspot experiences among the world's highest rates of HLF.
Paulo Sousa, Panagiotis Theodorou, Aline C. Martins, Antonio J. C. Aguiar, Akira Shibata, Belinda Kahnt   +5 more
wiley   +1 more source

Chromosome doubling by colchicine injection and haploidy induction in tropical genotypes of common and supersweet corn

Semina: Ciências Agrárias
The double-haploid technology in maize was developed in temperate environments, using germplasm and inducers adapted for these environments, with the aim of accelerating the obtaining of homozygous inbred lines.
Leticia de Freitas de Souza, Juliana Moraes Machado de Oliveira, Vitor Joaquim de Lucena, Otavio Gabriel Lalau Hoda, Iran de Azevedo Duarte, Bruno Figueiró Fregonezi, Josué Maldonado Ferreira   +6 more
doaj   +1 more source

Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program

New Phytologist, Volume 248, Issue 3, Page 1368-1384, November 2025.
Summary Algal blooms and their demise by viruses drive global‐scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal populations are constantly infected by viruses, resistant subpopulations frequently emerge after the infection.
Talia S. Shaler, Amir Fromm, Daniella Schatz, Shifra Ben‐Dor, Ester Feldmesser, Assaf Vardi   +5 more
wiley   +1 more source