Results 61 to 70 of about 3,218 (171)

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, Volume 58, Issue 11, November 2025.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

A rare case of near-haploid acute lymphoblastic leukemia

Leukemia Research Reports, 2019
Near-haploid acute lymphoblastic leukemia is seen in 50) has a good prognosis. The correct diagnosis was critical for this patient's prognosis and treatment.
William Gonzalez-Marques, Ann-Leslie Zaslav, Dhana Balakrishnan, Laura Hogan, Yupo Ma, Daniel Tully, Paula Fernicola, Roxana Ponce, Htien Lee, Theresa Mercado, Tahmeena Ahmed   +10 more
doaj   +1 more source

Integrating Population Genomics and Historical Occurrence Data to Assess the Impact of Land‐Use Changes on Centris Oil Bees in the Brazilian Cerrado

Molecular Ecology, Volume 34, Issue 22, November 2025.
ABSTRACT Habitat loss and fragmentation (HLF) are among the major drivers of bee decline, yet closely related species often show contrasting responses depending on their ecological and demographic traits. The Brazilian Cerrado biodiversity hotspot experiences among the world's highest rates of HLF.
Paulo Sousa, Panagiotis Theodorou, Aline C. Martins, Antonio J. C. Aguiar, Akira Shibata, Belinda Kahnt   +5 more
wiley   +1 more source

Impact of biophysicochemical factors on micropropagation, haploidy and doubled haploidy in strawberry (Fragaria sp.): A critical revisit

Current Plant Biology
Fragaria, commonly known as the strawberry, is one of the most economically important genera of fruit plants. Strawberries have a wide range of health-promoting and nutritious ingredients.
Ayyagari Ramlal, Pang Wei Quan, Ambika Rajendran, Sreeramanan Subramaniam   +3 more
doaj   +1 more source

Derivation of Haploid Trophoblast Stem Cells via Conversion In Vitro

iScience, 2019
Summary: Owing to their single genome, haploid cells are powerful to uncover unknown genes by performing genetic screening in mammals. However, no haploid cell line from an extraembryonic lineage has been achieved yet, which limits the application of ...
Keli Peng, Xu Li, Congyu Wu, Yuna Wang, Jian Yu, Jinxin Zhang, Qian Gao, Wenhao Zhang, Qian Zhang, Yong Fan, Yang Yu, Ling Shuai   +11 more
doaj   +1 more source

Identification of haploids and diploids in maize using seedling traits and flow cytometry

Crop Breeding and Applied Biotechnology, 2021
The seedling traits is a simple and non-destructive methodology used to identify haploids/diploids in maize. This study aimed at establishing an optimal germination temperature to evaluate this methodology and verify its effectiveness.
Samuel Henrique Kamphorst, Alessandra Guedes Baleroni, Fabrícia Ré, Andressa Pelozo, José Walter Pedroza Carneiro, Robson Marcelo Rossi, Carlos Alberto Scapim   +6 more
doaj  

Haploidy in Peach1

HortScience, 1974
Abstract Twenty-four haploids of peach [ Prunus persica (L.) Batsch] were obtained by visual selection in seedling populations growing in the greenhouse. Frequencies varied markedly between some progenies. Meiosis in pollen-mother cells was extremely irregular.
openaire   +1 more source

Effect of gamma ray irradiation doses on pollen viability and in-vitro germination in Citrus

The Indian Journal of Agricultural Sciences, 2016
Induction of haploid plants in fruit crops through gamma irradiated pollen technique is of paramount importance in modern fruit breeding to reduce the breeding cycle.
MANOJ KUNDU, ANIL DUBEY, S K MALIK
doaj   +1 more source

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.

PLoS Biology, 2015
X chromosomes are unusual in many regards, not least of which is their nonrandom gene content. The causes of this bias are commonly discussed in the context of sexual antagonism and the avoidance of activity in the male germline.
Laurence D Hurst, Avazeh T Ghanbarian, Alistair R R Forrest, FANTOM consortium, Lukasz Huminiecki   +4 more
doaj   +1 more source

Overexpression of Let-7a mitigates diploidization in mouse androgenetic haploid embryonic stem cells

iScience
Summary: Mouse androgenetic haploid embryonic stem cells (mAG-haESCs) can be utilized to uncover gene functions, especially those of genes with recessive effects, and to produce semicloned mice when injected into mature oocytes.
Wenteng He, Hongming Tang, Yuanyuan Li, Mingzhu Wang, Yuanyuan Li, Jiayu Chen, Shaorong Gao, Zhiming Han   +7 more
doaj   +1 more source