Results 41 to 50 of about 3,218 (171)

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, Volume 13, Issue 40, 17 July 2026.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Derivation of Mouse Haploid Trophoblast Stem Cells

Cell Reports, 2019
Summary: Trophoblast stem (TS) cells are increasingly used as a model system for studying placentation and placental disorders. However, practical limitations of genetic manipulation have posed challenges for genetic analysis using TS cells.
Tongtong Cui, Liyuan Jiang, Tianda Li, Fei Teng, Guihai Feng, Xuepeng Wang, Zhengquan He, Lu Guo, Kai Xu, Yihuan Mao, Leyun Wang, Xuewei Yuan, Liu Wang, Wei Li, Qi Zhou   +14 more
doaj   +1 more source

First case of near haploid philadelphia negative B-Cell acute lymphoblastic leukaemia relapsing as acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation

Leukemia Research Reports, 2020
Herein we present a female patient aged 61 with Philadelphia negative acute lymphoblastic leukaemia demonstrating near haploid karyotype and abnormal TP53 expression at diagnosis, who relapsed with lineage switch as Acute Monocytic Leukemia post ...
Claire Horgan, Charalampos Kartsios, Emmanouil Nikolousis, Paneesha Shankara, Bhuvan Kishore, Richard Lovell, Vidhya Murthy, Zbigniew Rudzki, Sara Dyer, Pam Holtom, Gillian Thompson, Maria Kaparou, Evgenia Xenou, Rebecca Lloyd, Indrani Venkatadasari, Alexandros Georgios Kanellopoulos   +15 more
doaj   +1 more source

Rapid sexual reproduction intensifies blooms of a mixotrophic dinoflagellate

Limnology and Oceanography, Volume 71, Issue 6, June 2026.
Abstract Sexual reproduction is fundamental to the ecology and evolution of eukaryotes, yet its dynamics in microbial eukaryotes are often cryptic. Dinophysis are specialist mixotrophs that must balance prey capture, cell division, and sexual recombination during blooms, but relatively little is known about the occurrence and role of sex in their ...
Serena Sung‐Clarke, Nour Ayache, Wenguang Zhang, Mengmeng Tong, Juliette L. Smith, Michael Brosnahan   +5 more
wiley   +1 more source

A Vertical Stacking Approach to Rapid Generation Cycling for Indoor Growth of Tall Annual Crops—The Case of Vicia faba L.

Plant Breeding, Volume 145, Issue 3, Page 637-648, June 2026.
ABSTRACT Accelerating breeding cycles through rapid generation turnover is a demonstrated strategy to improve the rate of genetic gain in a range of staple crops. This study presents a vertically stacked accelerated single‐seed descent (aSSD) protocol for faba bean (Vicia faba L.), aimed at rapid generation cycling while ensuring robust plant ...
Maria Pazos‐Navarro, Richard G. Bennett, Christine Munday, Robert Creasy, Samuel C. Catt, Judith Lichtenzveig, Federico Ribalta, Janine Croser   +7 more
wiley   +1 more source

Sensitivity and specificity of a novel preimplantation genetic test for aneuploidy (PGT-A) test detecting the presence and origin of the error: creation of haploid embryos as controls

BMJ Connections Clinical Genetics and Genomics
Introduction Conventional PGT-A methods using NGS sequencing can not detect polyploidy or haploidy, embryo parental origin, or differentiate between mitotic and meiotic abnormalities.
Santiago Munne, Michael Christensen, Hans Kim, Venkatesh Babu, Matthew Prasetyo, Nuno Costa-Borges, Nabil Arrach   +6 more
doaj   +1 more source

Spider Mites: Genetic Models to Inform Herbivore and Chelicerate Biology

BioEssays, Volume 48, Issue 5, May 2026.
Chelicerates include spiders, scorpions and ticks, and also spider mites that damage crops. Many of the features that make spider mites crop pests have facilitated their adoption as genetically tractable chelicerates. The expanding genetic toolkit developed using spider mites has potential to inform genetic studies in other chelicerates as well ...
Richard M. Clark, Sander De Rouck, Marilou Vandenhole, Thomas Van Leeuwen   +3 more
wiley   +1 more source

Haploidy and androgenesis in Drosophila. [PDF]

Proceedings of the National Academy of Sciences, 1995
Adrogenesis, development from paternal but not maternal chromosomes, can be induced to occur in some organisms, including vertebrates, but has only been reported to occur naturally in interspecific hybrids of the Sicilian stick insect. Androgenesis has not been described previously in Drosophila.
D J, Komma, S A, Endow
openaire   +2 more sources

A century of theories of balancing selection

Biological Reviews, Volume 101, Issue 2, Page 804-825, April 2026.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka, Martyna K. Zwoinska, Debora Goedert, Hanna Kokko, Xiang‐Yi Li Richter, Iain R. Moodie, Sofie Nilén, Colin Olito, Erik I. Svensson, Peter Czuppon, Tim Connallon   +10 more
wiley   +1 more source

Genome Sequence and Population Genomic Analysis of Cronartium quercuum f.sp. fusiforme

Forest Pathology, Volume 56, Issue 1, February 2026.
ABSTRACT Fusiform rust, caused by Cronartium quercuum f. sp. fusiforme (Cqf), is the most severe disease of planted southern pines in the south‐eastern United States. Despite the critical role pathogen genomics play in disease outcomes, the population structure and genetic variability of Cqf remain poorly characterised.
Makayla Rutski, Tania Quesada, Katherine Smith, Ina Schlathoelter, Jeremy T. Brawner, C. Dana Nelson, John M. Davis, Gary F. Peter   +7 more
wiley   +1 more source