Results 91 to 100 of about 290,368 (328)
Frontiers in Genetics, 2020 Type 2 diabetes (T2D) is a complex metabolic disease regulated by an interaction of genetic predisposition and environmental factors. To understand the genetic contribution in the development of diabetes, mice varying in their disease susceptibility were
Heja Aga +31 more
doaj +1 more source
Boosting Haplotype Inference with Local Search
, 2008 . A very challenging problem in the genetics domain is to infer haplotypes from genotypes. This process is expected to identify genes affecting health, disease and response to drugs.
Lynce, Ines +2 more
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Arthritis &Rheumatology, Accepted Article.Objectives The effect of the shared epitope (SE), and valine at position 11 (Val11) of HLA‐DRB1, on the activation of CD4+ T cells, is expected to be diminished by abatacept, a co‐stimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting.
Chuan Fu Yap +14 more
wiley +1 more source
Pharmacogenomics in the UK National Health Service: Progress towards implementation
British Journal of Clinical Pharmacology, EarlyView.Over the past decade there has been considerable and growing enthusiasm about the promise of using genomics to inform healthcare. In particular, using genetic data to inform prescribing practice has emerged as a compelling policy priority for health systems around the world, not least in the NHS.
John H. McDermott +3 more
wiley +1 more source
HGG Advances, 2023 Summary: Alzheimer disease (AD) is the most common form of senile dementia, with high incidence late in life in many populations including Caribbean Hispanic (CH) populations.
Andrea R.V.R. Horimoto +17 more
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A Major Root Architecture QTL Responding to Water Limitation in Durum Wheat
Frontiers in Plant Science, 2019 The optimal root system architecture (RSA) of a crop is context dependent and critical for efficient resource capture in the soil. Narrow root growth angle promoting deeper root growth is often associated with improved access to water and nutrients in ...
Samir Alahmad +13 more
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Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis
BMEMat, EarlyView.This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang +6 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive pharmacogenetic guidelines are not yet available for all anticancer drugs, evidence‐based recommendations exist for ...
Emma C. Bernsen +12 more
wiley +1 more source
Molecular population genetic analysis of Eriocheir japonica inhabiting Andeok Valley
Journal of Asia-Pacific Biodiversity, 2023 Eriocheir japonica inhabits rivers flowing into the East Sea, South Sea, and the coastal waters of Jeju-do in South Korea, Japan, and Sakhalin. The larvae migrate to freshwater, mature, and move to estuaries to spawn.
Dae-Ju Oh +3 more
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Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population
Genetics and Molecular Biology, 2014 Polymorphisms in the regulatory region of the CCR5 gene affect protein expression and modulate the progress of HIV-1 disease. Because of this prominent role, variations in this gene have been under differential pressure and their frequencies vary among ...
Samira H. Al-Mahruqi +5 more
doaj +1 more source