Results 41 to 50 of about 109,284 (237)

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Mitochondrial DNA discriminates distinct population of two deadly snakes (Reptilia: Elapidae) in Northeast India

Mitochondrial DNA. Part B. Resources, 2020
The DNA data of Indian snakes are scanty in the global database, especially from the northeastern states. The present study generated the mitochondrial Cytochrome b gene information of two morphologically identified deadly elapid species from Mizoram ...
Shantanu Kundu, Hmar Tlawmte Lalremsanga, Kaomud Tyagi, Lal Biakzuala, Vikas Kumar, Kailash Chandra   +5 more
doaj   +1 more source

Low Diversity and Strong Genetic Structure Between Feeding and Nesting Areas in Brazil for the Critically Endangered Hawksbill Sea Turtle

Frontiers in Ecology and Evolution, 2021
Marine turtle nesting areas are characterized by receiving several females every year. The species Eretmochelys imbricata, known as hawksbill turtle is listed as Critically Endangered by the IUCN, and has been the target of studies on genetic structure ...
Thyara Noely Simões, Ednilza Maranhão dos Santos, Alesandro Souza Santos, Fernanda Amato Gaiotto, Marco Antônio Costa, Elza Thaynara Cardoso de Menezes Assis, Vivian Chimendes da Silva Neves, Werlanne Mendes de Santana Magalhães, Rita Mascarenhas, Waltyane Alves Gomes Bonfim, Juliede Nonato Neves, Mirco Solé, Mirco Solé   +12 more
doaj   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

DNA barcoding elucidates the population genetic diversity of venomous cobra species (Reptilia: Elapidae) in Indo-Bangladesh region

Mitochondrial DNA. Part B. Resources, 2020
The DNA barcode data of venomous cobra species (Naja naja and Naja kaouthia) are limited in the global database, especially from India and Bangladesh. Owing to the rapid success of DNA barcoding for discriminating a variety of species around the world ...
Shantanu Kundu, Hmar Tlawmte Lalremsanga, Md. Mizanur Rahman, Md. Farid Ahsan, Lal Biakzuala, Vikas Kumar, Kailash Chandra, A. M. A. M. Zonaed Siddiki   +7 more
doaj   +1 more source

Association of the Gelatinase B/Metalloproteinase 9 (MMP-9) Gene Haplotype in Systemic Lupus Erythematosus (SLE) in the Pediatric Egyptian Population

Children, 2022
Permanent systemic inflammation is a defining feature of systemic lupus erythematosus (SLE), which affects multiple organs. Gelatinase B/matrix metalloproteinase-9 (MMP-9) is an essential protease investigated in inflammation that has been linked to SLE.
Zeinab R. Attia, Mohamed M. Zedan, Thuraya M. Mutawi, Entsar A. Saad, Rania A. Abd El Azeem, Mohamed A. El Basuni   +5 more
doaj   +1 more source

Minimal haplotype tagging [PDF]

Proceedings of the National Academy of Sciences, 2003
The high frequency of single-nucleotide polymorphisms (SNPs) in the human genome presents an unparalleled opportunity to track down the genetic basis of common diseases. At the same time, the sheer number of SNPs also makes unfeasible genomewide disease association studies.
Sebastiani, P, Lazarus, R, Weiss, ST, Kunkel, LM, Kohane, IS, Ramoni, MF   +5 more
openaire   +3 more sources

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Wen‐Xue Li, Qingguo Du   +7 more
wiley   +1 more source

Genetic Diversity Resonates With Conservation Strategies: A Case Study of Labeo rohita Population

Ecology and Evolution
Conservation strategies often overlook genetic diversity, which is essential for biodiversity preservation and species adaptability. Efforts are minimal for low‐income countries like Bangladesh.
Md. Mahfuzur Rahman, Khandaker Asif Ahmed, Md. Golam Rabbane, Mohammad Shamimul Alam   +3 more
doaj   +1 more source