Results 41 to 50 of about 122,711 (274)

MetaTrass: A high‐quality metagenome assembler of the human gut microbiome by cobarcoding sequencing reads

iMeta, Volume 1, Issue 4, December 2022., 2022
We developed a tool to get high‐quality genomes with high taxonomic resolution by combining the cobarcoding information with public references. Compared with the conventional combination strategies, our pipeline generated a large number of high‐quality genomes for the human microbial cobarcoding data sets. Abstract Metagenomic evidence of great genetic
Yanwei Qi, Shengqiang Gu, Yue Zhang, Lidong Guo, Mengyang Xu, Xiaofang Cheng, Ou Wang, Ying Sun, Jianwei Chen, Xiaodong Fang, Xin Liu, Li Deng, Guangyi Fan   +12 more
wiley   +1 more source

Disequilibrium linkage (gametic disequilibrium) of structural genes in the bovine population

Аграрная наука Евро-Северо-Востока, 2021
In the population of Kholmogor cattle (n=824), gametic disequilibrium was studied for alleles of the polymorphic loci β-Lg (LGB), β-Cn (CSN2) and æ-Cn (CSN3). In purebred Kholmogor cattle, the β-casein polymorphism is determined by three alleles with the
V. S. Matyukov, V. G. Zainullin
doaj   +1 more source

Variable-length haplotype construction for gene-gene interaction studies [PDF]

IEEE Engineering in Medicine and Biology Magazine, 28(4), 25-31, 2013
This paper presents a non-parametric classification technique for identifying a candidate bi-allelic genetic marker set that best describes disease susceptibility in gene-gene interaction studies. The developed technique functions by creating a mapping between inferred haplotypes and case/control status. The technique cycles through all possible marker
arxiv   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Exome‐based new allele‐specific PCR markers and transferability for sodicity tolerance in bread wheat (Triticum aestivum L.)

Plant Direct, 2023
Targeted exome‐based genotype by sequencing (t‐GBS), a sequencing technology that tags SNPs and haplotypes in gene‐rich regions was used in previous genome‐wide association studies (GWAS) for sodicity tolerance in bread wheat.
Roopali Bhoite, Rosemary Smith, Urmil Bansal, Mirza Dowla, Harbans Bariana, Darshan Sharma   +5 more
doaj   +1 more source

Distribution patterns of HLA-A^*, B^*, DRB1^* allele groups among persons who underwent COVID-19

Медицинская иммунология, 2021
The main histocompatibility complex — HLA system (Human Leukocyte Antigens) is among the most important genetic factors determining response of humans to infectious agents.
L. N. Bubnova, I. E. Pavlova, A. S. Berkos, M. A. Terentyeva, T. V. Glazanova, L. V. Erokhina, E. V. Belyaeva, A. V. Chechetkin, N. S. Bashketova, I. G. Chkhindzheria, M. А. Kozhemyakina, D. V. Azarov, R. N. Kuznetsova, Areg A. Totolyan   +13 more
doaj   +1 more source

Exploring Parthenium weed biotypes by chloroplast DNA barcode analysis [PDF]

Planta Daninha, 2020
Background: Parthenium weed (Parthenium hysterophorus L.) is an invasive weed that has invaded vast regions of Pakistan in a relatively very short period of a decade or two, threatening the crop fields of the agrarian fed country.
Tehmina Anjum, Rasheda Jabeen, Steve Adkins, Waheed Akram   +3 more
doaj   +1 more source

Heterozygous variants in AP4S1 are not associated with a neurological phenotype

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function. We critically evaluate this claim against clinical observations in 28 heterozygous carriers of the same
Vicente Quiroz, Umar Zubair, Luca Schierbaum, Amy Tam, Nicole Battaglia, Joshua Rong, Habibah A. P. Agianda, Julian E. Alecu, Kathryn Yang, Darius Ebrahimi‐Fakhari   +9 more
wiley   +1 more source

Biomaterials‐based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents

Journal of Biomedical Materials Research Part A, Volume 111, Issue 2, Page 185-197, February 2023., 2023
Abstract Type 1 diabetes (T1D) presents with two therapeutic challenges: the need to correct underlying autoimmunity and restore β‐cell mass. We harnessed the unique capacity of regulatory T cells (Tregs) and the T cell receptor (TCR) to direct tolerance induction along with tissue‐localized delivery of therapeutic agents to restore endogenous β‐cell ...
Gregory P. Marshall, Judit Cserny, Chun‐Wei Wang, Benjamin Looney, Amanda L. Posgai, Rhonda Bacher, Benjamin Keselowsky, Todd M. Brusko   +7 more
wiley   +1 more source

Advances in methodologies for detecting MHC-B variability in chickens

Poultry Science, 2020
The chicken major histocompatibility B complex (MHC-B) region is of great interest owing to its very strong association with resistance to many diseases. Variation in the MHC-B was initially identified by hemagglutination of red blood cells with specific
J.E. Fulton
doaj