Results 11 to 20 of about 37,781 (227)

The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO

Critical Care, 2022
Background Increased plasma concentrations of circulating cell-free hemoglobin (CFH) are supposed to contribute to the multifactorial etiology of acute kidney injury (AKI) in critically ill patients while the CFH-scavenger haptoglobin might play a ...
Jan A. Graw, Philip Hildebrandt, Alexander Krannich, Felix Balzer, Claudia Spies, Roland C. Francis, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk, Oliver Hunsicker   +9 more
doaj   +2 more sources

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. [PDF]

PLoS ONE, 2018
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states ...
John D Belcher, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, Hao Nguyen, Phong Nguyen, Trevor Killeen, Sylvia M Miescher, Nathan Brinkman, Karl A Nath, Clifford J Steer, Gregory M Vercellotti   +12 more
doaj   +2 more sources

Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: A prospective study

Journal of the European Academy of Dermatology and Venereology, 2023
Hidradenitis suppurativa (HS) is a chronic inflammatory disease that is highly correlated with obesity. Haptoglobin serum levels have recently been recognized as an important biomarker linking obesity with chronic inflammation.
N. A. Rached, T. Gambichler, L. Ocker, M. Skrygan, C. Seifert, C. Scheel, E. Stockfleth, F. Bechara, Abu Rached, C. Scheel, al Haptoglobin   +10 more
semanticscholar   +1 more source

Immunohistochemical Expression of Haptoglobin in Skin Lesions of Hidradenitis Suppurativa. [PDF]

Life (Basel)
Background: Meta-inflammation is a hallmark of hidradenitis suppurativa (HS). Research on meta-inflammation in HS is growing, but there is still no research on haptoglobin as an inflammatory protein in lesional HS skin.
Abu Rached N, Telkemeyer H, Skrygan M, Doerler M, Haven Y, Ocker L, Myszkowski D, Meyer T, Stücker M, Stockfleth E, Bechara FG.   +10 more
europepmc   +2 more sources

The relationship between serum erythropoietin, hepcidin, and haptoglobin levels with disease severity and other biochemical values in patients with COVID‐19

International Journal of Laboratory Hematology, 2021
Studies have shown that iron metabolism is affected by coronavirus disease 19 (COVID‐19), which has spread worldwide and has become a global health problem.
Sema Yağcı, E. Serin, Özlem Acicbe, M. Zeren, M. Odabaşı   +4 more
semanticscholar   +1 more source

Haptoglobin-Conjugated Gold Nanoclusters as a Nanoantibiotic to Combat Bacteremia

Nanomaterials, 2022
Gold nanoclusters have revealed great potential as nanoantibiotics due to their superior chemical and physical characteristics. In this study, a peptide with 83 amino acids derived from haptoglobin was utilized as a surface ligand to synthesize gold ...
Hsiu-Yi Chu, Lung-Ching Chen, Tsung-Rong Kuo, Chun-Che Shih, Sibidou Yougbaré, Yu-Han Chen, Tsai-Mu Cheng   +6 more
doaj   +1 more source

Progress on haptoglobin and metabolic diseases

World Journal of Diabetes, 2021
Haptoglobin (Hp) is an acidic glycoprotein, existing in the serum and other body fluids of human beings and a variety of mammals. Hp is produced in the liver, white adipose tissue, and the kidney.
Bao-Nian Wan, Shigao Zhou, Miao Wang, Xiao Zhang, G. Ji   +4 more
semanticscholar   +1 more source

Nucleated Red Blood Cells Secrete Haptoglobin to Induce Immunosuppressive Function in Monocytes. [PDF]

J Immunol Res
Nucleated red blood cells (NRBCs) are precursors of red blood cells (RBCs), but also possess variety of immunomodulatory effects. However, among the three types of NRBCs, the immunological effects of human CD45− NRBCs remain largely unknown.
Takeuchi S, Fujiyama S, Nagafuji M, Mayumi M, Saito M, Obata-Yasuoka M, Hamada H, Miyazono Y, Takada H.   +8 more
europepmc   +2 more sources

Haptoglobin treatment contributes to regulating nitric oxide signal and reduces oxidative stress in the penis: A preventive treatment for priapism in sickle cell disease

Frontiers in Physiology, 2022
Background: In sickle cell disease (SCD), reduced bioavailability of endothelial NO and cGMP results in reduced expression of phosphodiesterase type 5 (PDE5), thus impairing the penile erection control mechanism and resulting in prolonged penile erection
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fábio Henrique Silva, Fábio Henrique Silva   +8 more
doaj   +1 more source

Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women. [PDF]

PLoS ONE, 2009
BackgroundHp(2) alleles of the haptoglobin alpha-chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might
Francisco Alvarez-Blasco, Ma Angeles Martínez-García, Manuel Luque-Ramírez, Naiara Parraza, José L San Millán, Héctor F Escobar-Morreale   +5 more
doaj   +1 more source