Results 71 to 80 of about 37,781 (227)

Phenotypic Shifts in Macrophages Within Advanced Atherosclerotic Plaques in Humans

FASEB BioAdvances, EarlyView.
The transition from a non‐atherosclerotic to an atherosclerotic artery is associated with a shift in macrophage phenotypes. In the homeostatic environment of a non‐atherosclerotic artery, macrophages are predominantly anti‐inflammatory, anti‐atherogenic.
Barbora Muffova, Sona Kauerova, Hana Bartuskova, Karel Paukner, Libor Janousek, Helena Cermakova, Jiri Fronek, Marek Kollar, Marek Petras, Jan Pitha, Rudolf Poledne, Ivana Kralova Lesna   +11 more
wiley   +1 more source

Free Foetal Haemoglobin in Severe Early‐Onset Foetal Growth Restriction: A Prospective Multi‐Centre Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess foetal circulating free foetal haemoglobin (fHbF) levels and heme defences, correlated to foetal circulatory biometry and foetal sex in severe early‐onset foetal growth restriction (FGR). Design, Setting and Population A prospective study severe early‐onset foetal growth restriction pregnancies with close clinical ...
Adam Brook, Georgia Baynes, Jonathan Scargill, Angelos Evangelinos, Charlotte Brennan‐Richardson, Freya Dow, Yuval Ginsberg, Tal Weissbach, Jana Brodszki, Eva Hansson, Anke Diemert, Kurt Hecher, Katarzyna Maksym, Neil Marlow, Rebecca N. Spencer, Anna L. David, Stefan R. Hansson, Paul Brownbill   +17 more
wiley   +1 more source

Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients

Critical Care, 2017
Background Intravascular haemolysis has been associated with acute kidney injury (AKI) in different clinical settings (cardiac surgery, sickle cell disease). Haemolysis occurs frequently in critically ill burn patients.
François Dépret, Chloé Dunyach, Christian De Tymowski, Maïté Chaussard, Aurélien Bataille, Axelle Ferry, Nabila Moreno, Alexandru Cupaciu, Sabri Soussi, Mourad Benyamina, Alexandre Mebazaa, Kevin Serror, Marc Chaouat, Jean-Pierre Garnier, Romain Pirracchio, Matthieu Legrand, for the PRONOBURN group   +16 more
doaj   +1 more source

The Multifaceted Haptoglobin in the Context of Adipose Tissue and Metabolism.

Endocrine reviews, 2016
Obesity is a low chronic inflammatory state because several inflammatory factors are increased in obese subjects, this having important implications for the onset of obesity-associated complications.
M. Maffei, I. Barone, G. Scabia, F. Santini   +3 more
semanticscholar   +1 more source

Iron overload in hereditary spherocytosis: Are genetic factors the cause?

British Journal of Haematology, EarlyView.
Summary Non‐transfusional iron overload (IOL) in hereditary spherocytosis (HS) is poorly documented compared with other red blood cell disorders. We studied 13 HS adults with confirmed IOL to identify potential genetic factors. Using a next‐generation sequencing panel of 46 genes related to HS, anaemia and iron metabolism, we found no association ...
Lucie Donaty, Muriel Giansily‐Blaizot, Ivan Bertchansky, Séverine Cunat, Vincent Azoury, Perrine Mahe, Patricia Aguilar Martinez   +6 more
wiley   +1 more source

Systemic lupus erythematosus‐associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice

British Journal of Haematology, Volume 206, Issue 4, Page 1213-1217, April 2025.
Summary We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi‐organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic
Urshita Sinha, Suman Setty, Céleste Pilon, Julia J. Brown, Maria Armila Ruiz, Guohui Ren, Joyce Rauch, Santosh L. Saraf, Jerrold S. Levine   +8 more
wiley   +1 more source

The Cryo-EM structure of human CD163 bound to haptoglobin-hemoglobin reveals molecular mechanisms of hemoglobin scavenging

Nature Communications
CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron.
Anders Etzerodt, Jakob Hauge Mikkelsen, Morten Torvund-Jensen, Dorle Hennig, Thomas Boesen, Jonas Heilskov Graversen, Søren Kragh Moestrup, Justin M. Kollman, Christian Brix Folsted Andersen   +8 more
doaj   +1 more source

Diagnostic Role of Serum Haptoglobin level in Early Onset Neonatal Sepsis [PDF]

Iranian Journal of Neonatology, 2016
Background: Introduction: Searching for an ideal marker for diagnosing neonatal infection is still an important concern in every country. There are many biomarkers reported for neonatal sepsis.
Seiedmohsen Emami, Majid Kalani, Gholam Ali Mohaddes   +2 more
doaj  

Fucosylation Is a Promising Target for Cancer Diagnosis and Therapy

Biomolecules, 2012
Oligosaccharides, sequences of carbohydrates conjugated to proteins and lipids, are arguably the most abundant and structurally diverse class of molecules.
Shinichiro Shinzaki, Hitoshi Matsumoto, Tsutomu Nakagawa, Mika Terao, Cheng-Cheng Tan, Naoko Terao, Kenta Moriwaki, Eiji Miyoshi, Yoshihiro Kamada   +8 more
doaj   +1 more source

Insights on N-glycosylation of human haptoglobin and its association with cancers.

Glycobiology, 2016
Protein glycosylation is one of the most significant post-translation modifications and plays a critical role in various biological functions. Haptoglobin (Hp) is one of the acute-phase response proteins secreted by liver.
Shu Zhang, Shuxin Shang, Wei Li, X. Qin, Yin‐kun Liu   +4 more
semanticscholar   +1 more source