Results 71 to 80 of about 956,014 (301)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Structural mechanics model and its fracture mode of variable-thickness roof strata in large mining height stope

Meitan kexue jishu
Understanding the fracture movement laws of rock strata plays an important role in the control of mine pressure and the prevention and control of dynamic disasters such as strong mine seismic events in stope.
Yangbo LU, Shaohong YAN, Kunyou ZHOU, Yuanjie WANG, Peng FU, Chenxi ZHANG   +5 more
doaj   +1 more source

Dynamics of Quark-Gluon-Plasma Instabilities in Discretized Hard-Loop Approximation

, 2005
Non-Abelian plasma instabilities have been proposed as a possible explanation for fast isotropization of the quark-gluon plasma produced in relativistic heavy-ion collisions.
A.H. Mueller, Anton Rebhan, E. Shuryak, H. Nastase, J.O. Andersen, Michael Strickland, O.P. Pavlenko, P. Arnold, P. Arnold, Paul Romatschke, U. Kraemmer, U.W. Heinz, Y.E. Pokrovsky, Y.E. Pokrovsky, Y.V. Kovchegov   +14 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A More Reasonable Definition of Failure Mode for Mechanical Systems Using Meta-Action

IEEE Access, 2019
Identification of failure modes is a vital work in the process of failure mode and effect analysis (FMEA). Since the traditional failure mode is defined as a specific function failure or a part failure, there are uncountable failure modes for mechanical ...
Hui Yu, Genbao Zhang, Yan Ran
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A model of the effect of collisions on QCD plasma instabilities

, 2006
We study the effect of including a BGK collisional kernel on the collective modes of a QCD plasma which has a hard-particle distribution function which is anisotropic in momentum space.
Greiner, Carsten, Schenke, Bjoern, Strickland, Michael, Thoma, Markus H.   +3 more
core   +1 more source

Perturbative QCD at finite temperature and density [PDF]

, 1997
This is a comprehensive review on the perturbative hot QCD including the recent developments. The main body of the review is concentrated upon dealing with physical quantities like reaction rates. Contents: \S1. Introduction, \S2.
Niégawa, A.
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Generalized parton distributions in an AdS/QCD hard-wall model

, 2012
We use a matching procedure of sum rules relating the electromagnetic form factors to generalized parton distributions (GPDs) and AdS modes. In this way, in the framework of an AdS/QCD hard-wall model, the helicity-independent GPDs of quarks for the ...
Gutsche, Thomas, Lyubovitskij, Valery E., Schmidt, Ivan, Vega, Alfredo   +3 more
core   +1 more source