Results 51 to 60 of about 1,935,322 (253)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Lyapunov Modes in Hard-Disk Systems
, 2005 We consider simulations of a two-dimensional gas of hard disks in a rectangular container and study the Lyapunov spectrum near the vanishing Lyapunov exponents. To this spectrum are associated “eigen-directions”, called Lyapunov modes.
Eckmann, Jean-Pierre +3 more
core +1 more source
Collective modes in simple melts: Transition from soft spheres to the hard sphere limit
Scientific Reports, 2017 We study collective modes in a classical system of particles with repulsive inverse-power-law (IPL) interactions in the fluid phase, near the fluid-solid coexistence (IPL melts).
Sergey Khrapak +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
DEM construction of binary hard sphere crystals and radical tessellation
AIP Advances, 2018 In this paper, four binary hard sphere crystals were numerically constructed by discrete element method (DEM) through different packing modes under three-dimensional (3D) mechanical vibration.
Defeng Wang +5 more
doaj +1 more source
Soft thermal contributions to 3-loop gauge coupling
Journal of High Energy Physics, 2018 We analyze 3-loop contributions to the gauge coupling felt by ultrasoft (“magnetostatic”) modes in hot Yang-Mills theory. So-called soft/hard terms, originating from dimension-six operators within the soft effective theory, are shown to cancel 1097/1098 ...
M. Laine, P. Schicho, Y. Schröder
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Zhongguo dizhi zaihai yu fangzhi xuebaoThe mountainous region of southwestern China is characterized by complex geological structures, where significant variations in lithology and stratum attitudes within the same slope section are frequently encountered.
Wei LONG, Pin LIU, Quanchuan CHEN
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Lyapunov Modes in Hard-Disk Systems [PDF]
, 2018 We consider simulations of a two-dimensional gas of hard disks in a rectangular container and study the Lyapunov spectrum near the vanishing Lyapunov exponents. To this spectrum are associated "eigen-directions”, called Lyapunov modes.
Posch, Harald +3 more
core