Results 51 to 60 of about 84,533 (300)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Lyapunov spectrum and modes of the equilibrium many-hard-disks system

open access: yes, 2010
The quasi-one-dimensional (QOD), many-hard-disks system is a model of the motion of N circular particles within a long, narrow two-dimensional channel. Interaction consists of elastic hard collisions between neighbouring particles.
Chung, Tony
core   +1 more source

Unexpected formation modes of the first hard binary in core collapse [PDF]

open access: yesNew Astronomy, 2012
15 pages, 11 figures, 1 table, submitted to New ...
Tanikawa, Ataru   +2 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How does hard technology innovation drive semiconductor enterprises’ upgrading and success? An empirical study based on configurational paths and influencing mechanisms

open access: yesJournal of Innovation & Knowledge
As China’s economic restructuring and industrial upgrading advances, hard technology innovation has become a critical driving force for promoting industrial transformation and enhancing corporate market competitiveness.
Liang Han, Li Yue
doaj   +1 more source

Silicon integrated multi-mode ring resonator

open access: yesNanophotonics, 2021
Ring resonator is an essential element in silicon integrated circuit, it is widely used as filter, wavelength multiplexer and switch in single-mode operation regime.
Ye Mengyuan   +4 more
doaj   +1 more source

On relation between the 1.5 μm Er-related emission and 9 μm vibrational modes of oxygen in silicon

open access: yes, 2009
We demonstrate that excitation of Er3+ ions embedded in crystalline silicon is effectively quenched when vibrational modes of interstitial oxygen are activated.
Minissale, S.   +2 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Unified study of viscoelasticity and sound damping in hard and soft amorphous solids

open access: yesCommunications Physics
Amorphous solids are diverse materials that take on various forms such as structural glasses, granular materials, foams, emulsions, and biological systems.
Hideyuki Mizuno   +3 more
doaj   +1 more source

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