Results 71 to 80 of about 1,935,322 (253)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Computation of Real Normal Modes from Complex Eigenvectors [PDF]
, 2006 A method for the computation of real normal modes from complex eigenvectors is described in this paper. The method is based on the exact eigensystem equations, which commonly cannot be used due the problem of modal truncation.
Füllekrug, Ulrich
core
IEEE Photonics Journal, 2017 We propose a new method to generate orbital angular momentum (OAM) mode by superposing multiple LP11 modes with microphase difference distributed along fiber propagation. This way, OAM mode can be generated by superposing a series of LP11 mode with phase
Yangjin Li +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Experimental Analysis of Communitation Process of Power Semiconductor Transistor’s Structures
Advances in Electrical and Electronic Engineering, 2007 The paper deals with testing device designed for experimental examination of processes in power electronics devices during various switching modes is described.
Pavol Spanik +4 more
doaj
Shock and Vibration, 2017 This research has experimentally investigated the influence on vibration characteristics of thin cantilever cylindrical shell (TCS) with hard coating under cantilever boundary condition.
Hui Li +3 more
doaj +1 more source
ANALYSIS AND SELECTION OF RATIONAL CUTTING MODES WHILE USING HARD-ALLOY TOOL FOR SHAFT TURNING
Наука и техника, 2018 Turning machining of such parts as shafts is considered as the most widely-spread method formanufacturing units, mechanisms and machinery. While doing so it is necessary to ensure high quality of shaft turning with the help of a hard-alloy tool (accuracy
V. K. Sheleg +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Energy Science & EngineeringIn response to the dynamic hazards caused by the fracture of thick‐hard strata in deep mining, this study investigates their progressive breaking law by integrating theoretical analysis based on thick plate theory with physical simulation experiments.
Meilu Yu, Jianping Zuo
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source