Results 71 to 80 of about 84,533 (300)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Meitan kexue jishuUnderstanding the fracture movement laws of rock strata plays an important role in the control of mine pressure and the prevention and control of dynamic disasters such as strong mine seismic events in stope.
Yangbo LU +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A More Reasonable Definition of Failure Mode for Mechanical Systems Using Meta-Action
IEEE Access, 2019 Identification of failure modes is a vital work in the process of failure mode and effect analysis (FMEA). Since the traditional failure mode is defined as a specific function failure or a part failure, there are uncountable failure modes for mechanical ...
Hui Yu, Genbao Zhang, Yan Ran
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2012 We present a novel setup in which real objects made of different materials can be mixed optically. For the materials we chose mutually very different materials, which we assume to represent canonical modes.
Koenderink, J.J. (author) +14 more
core +1 more source
Adaptive output feedback control based on neural networks: application to flexible aircraft control [PDF]
, 2009 One of the major challenges in aeronautical flexible structures control is the uncertain for the non stationary feature of the systems. Transport aircrafts are of unceasingly growing size but are made from increasingly light materials so that their ...
J. Bordeneuve-Guibé +5 more
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Hard Disks on the Hyperbolic Plane
, 2007 We examine a simple hard disk fluid with no long range interactions on the two-dimensional space of constant negative Gaussian curvature, the hyperbolic plane.
Kamien, Randall D., Modes, Carl D.
core