Results 81 to 90 of about 92,483 (291)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Shear behavior of intact loess and spatiotemporal evolution of mesoscopic damage: Dynamic identification using CT technology

Journal of Rock Mechanics and Geotechnical Engineering
The shear behavior of intact loess is intricately linked to the spatiotemporal evolution of its mesoscopic characteristics. Understanding this relationship is crucial for comprehending and preventing loess landslides.
Haiman Wang, Dong Liao, Wankui Ni, Kangze Yuan, Yexia Guo   +4 more
doaj   +1 more source

Soil plasticity with a different porosity

MATEC Web of Conferences, 2017
The model of soils with different porosity in the framework of the associated theory of plasticity is presented The single analytical function describes the loading surface in the stress space.
Klovanych Sergii, Malyszko Leszek
doaj   +1 more source

Rational interpretation of the postulates in plasticity

Results in Physics, 2014
This article is mainly focussed on revisited of the two well-known postulates of plasticity, i.e., the Drucker and the Il’iushin postulate, and it describes their rational interpretation within the framework of irreversible thermodynamics and using ...
Bohua Sun
doaj   +1 more source

A State-Dependent Constitutive Model for Gas Hydrate-Bearing Sediments Considering Cementing Effect

Journal of Marine Science and Engineering, 2020
This paper presents a state-dependent constitutive model for gas hydrate-bearing sediments (GHBS), considering the cementing effect for simulating the stress–strain behavior of GHBS. In this work, to consider the influence of hydrate on matrix samples in
Qingmeng Yuan, Liang Kong, Rui Xu, Yapeng Zhao   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Numerical prediction of bearing capacity and settlement of shallow foundation on overconsolidated clays using the Hardening State Parameter model [PDF]

Građevinski Materijali i Konstrukcije
A numerical analysis was performed to investigate the bearing capacity and settlement behaviour of shallow foundations on overconsolidated clays. Finite element analyses were conducted in PLAXIS 2D using two constitutive soil models: the Modified Cam ...
Obradović Nikola, Jocković Sanja
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source