Results 81 to 90 of about 5,135,844 (257)

Thermal and Athermal Effects of High-Density Pulsed Electric Current on Strain-Hardening Relief in Cold-Rolled A6061 Under Liquid Nitrogen

Journal of Manufacturing and Materials Processing
Understanding the respective roles of thermal and athermal effects during electric current treatment is critical for advancing current-assisted processing of metallic materials.
Shaojie Gu, Xiaoming Yu, Yanhong Peng, Lusheng Wang, Sungmin Yoon, Yi Cui, Yasuhiro Kimura, Yasuyuki Morita, Yuhki Toku, Yang Ju   +9 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Fiber Systems in Strain-Hardening Cementitious Composites: A Review of Multiscale Mechanisms and Engineering Applications

Buildings
Strain-hardening cementitious composites (SHCCs) achieve tensile strain hardening and distributed multiple cracking through coordinated matrix cracking, fiber bridging, and interfacial stress transfer.
Dawen Guo, Wei Hu, Junzhe Qin, Jie Zhang, Chao Zhang, Zheng Guo, Yongchang Guo   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Shear behavior of intact loess and spatiotemporal evolution of mesoscopic damage: Dynamic identification using CT technology

Journal of Rock Mechanics and Geotechnical Engineering
The shear behavior of intact loess is intricately linked to the spatiotemporal evolution of its mesoscopic characteristics. Understanding this relationship is crucial for comprehending and preventing loess landslides.
Haiman Wang, Dong Liao, Wankui Ni, Kangze Yuan, Yexia Guo   +4 more
doaj   +1 more source

On shakedown theorems in hardening plasticity

, 2001
The model of generalized standard materials gives a convenient framework to extend Koiter's shakedown theorems into hardening plasticity. The extension of the static shakedown theorem (Melan–Koiter's theorem), proposed previously in [5], is considered ...
Duc Chinh Pham, Pham, Duc Chinh, Nguyen, Quoc Son, Quoc Son Nguyen   +3 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Thermodynamic Formulation of Plastic Work Hardening Materials

, 1999
Thermodynamic formulation of elastoplastic or viscoplastic models using the internal variable approach currently does not include models using the plastic work as a hardening variable.
Ristinmaa, Matti,, Lund University.
core   +2 more sources